Comparison between single-photon emission computed tomography/computed tomography and ultrasound in preoperative detection of parathyroid adenoma
| Autor: | Nazim Coskun, Aynur Albayrak, Bedri Seven, Berna Okudan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Technetium Tc 99m Sestamibi Single Photon Emission Computed Tomography Computed Tomography chemistry.chemical_element Single-photon emission computed tomography Technetium 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Humans Medicine Radiology Nuclear Medicine and imaging Aged Retrospective Studies Ultrasonography Parathyroid adenoma Hyperparathyroidism medicine.diagnostic_test business.industry Ultrasound Retrospective cohort study General Medicine Middle Aged medicine.disease Parathyroid Neoplasms chemistry 030220 oncology & carcinogenesis Preoperative Period Female business Nuclear medicine Primary hyperparathyroidism Emission computed tomography |
| Zdroj: | Nuclear Medicine Communications. 40:1211-1215 |
| ISSN: | 0143-3636 |
| Popis: | Objective The aim of this study was to evaluate the accuracy of technetium- 99m-methoxyisobutylisonitrile (Tc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) and ultrasound in preoperative localization of single parathyroid adenomas (PTAs) in patients with primary hyperparathyroidism (pHPT) who would be suitable for minimally invasive parathyroidectomy (MIP). Methods A retrospective study of 143 consecutive patients with biochemical evidence of hyperparathyroidism who underwent preoperative localization of parathyroid lesions using Tc-MIBI SPECT/CT and ultrasound, and proceeded to parathyroid surgery at our institution from January 2013 to January 2018. Of these, 125 had single adenomas and are the subject of this study. The sensitivity, positive predictive value (PPV) and accuracy of the two imaging techniques for the accurately identification and lateralization of PTAs were determined using histopathology as the criterion standard. Results Of 125 PTAs, the correct identification and lateralization were significantly higher by SPECT/CT than ultrasound. SPECT/CT and ultrasound detected lesions with histopathologically proven PTAs in 116 and 95 patients, respectively. The sensitivity, PPV and accuracy were 92.17, 94.64 and 87.60%, respectively, for SPECT/CT and 75.89, 90.43 and 70.25%, respectively, for ultrasound in lateralization analysis. Conclusions The results of our study indicate that Tc-MIBI SPECT/CT is more accurate than ultrasound for the preoperative identification of single PTAs in patients with pHPT who are candidates for MIP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|