Cleavage of amyloid beta peptide during constitutive processing of its precursor
| Autor: | Russell W. Blacher, Donald McClure, Eric C. Beattie, Tilman Oltersdorf, Frederick Esch, Pamela S. Keim, Alan R. Culwell, Pamela J. Ward |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Amyloid Amyloid beta BACE1-AS Molecular Sequence Data Transfection Amyloid beta-Protein Precursor Internal medicine mental disorders medicine Amyloid precursor protein Humans Senile plaques Amino Acid Sequence Protein Precursors Multidisciplinary biology P3 peptide medicine.disease Peptide Fragments Cell biology Biochemistry of Alzheimer's disease Endocrinology Alpha secretase biology.protein Alzheimer's disease Protein Processing Post-Translational |
| Zdroj: | Science (New York, N.Y.). 248(4959) |
| ISSN: | 0036-8075 |
| Popis: | The amyloid beta peptide (A beta P) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant A beta P deposition in the brains of patients with Alzheimer's disease suggests that altered APP processing may represent a key pathogenic event. Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the A beta P, thus preventing A beta P deposition. A deficiency of this processing event may ultimately prove to be the etiological event in Alzheimer's disease that gives rise to senile plaque formation. |
| Databáze: | OpenAIRE |
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