Serum adiponectin levels and adiponectin +276 G/T gene polymorphism in newborns with large and small birth weights
| Autor: | E. Esin Yalinbas, RAZİYE AKCILAR |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 35:10638-10646 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767058.2022.2150073 |
| Popis: | Adiponectin may be an important indicator in the regulation of fetal and neonatal growth due to its metabolism, energy balance, and insulin-sensitizing action. The current study's goal was to determine if there is a link between adiponectin +276 G/T gene polymorphism and serum adiponectin level in newborns classified as appropriate for gestational age (AGA), small for gestational age (SGA), or large for gestational age (LGA).The study included newborns classified as AGA (The SGA newborns had significantly lower levels of serum adiponectin than the AGA and LGA newborns. There were statistically significant differences between the genotype frequencies (GG, GT, TT) of the SGA newborns (29.9%, 45.1%, 13.9%), the AGA newborns (41.6%, 20.7%, 44.4%), and the LGA newborns (28.6%, 34.1%, 41.7%) (chi-square = 15.8; degree of freedom = 4;The results of the current study suggest that the adiponectin +276 G/T gene polymorphism was associated with an increased chance of being born SGA or LGA. The effect of this polymorphism on newborn birth size was independently associated with serum adiponectin levels. Adiponectin may play a role in fetal growth. |
| Databáze: | OpenAIRE |
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