Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge
| Autor: | Qiuli Lu, Liangdi Sun, Wei Li, Xiao Lu, Yuqing Zhao, Li Xiang, Peng Liu, Hongcui Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell Survival Morris water navigation task Oxidative phosphorylation Hippocampal formation Biology Pharmacology medicine.disease_cause Neuroprotection Hippocampus 03 medical and health sciences chemistry.chemical_compound Mice Neuroblastoma 0302 clinical medicine Sapindaceae Alzheimer Disease Cell Line Tumor medicine Animals Humans Maze Learning Amyloid beta-Peptides Molecular Structure General Medicine Glutathione Xanthoceras biology.organism_classification Peptide Fragments 030104 developmental biology chemistry Gene Expression Regulation Cell culture Cytokines 030217 neurology & neurosurgery Oxidative stress Food Science |
| Zdroj: | Foodfunction. 11(3) |
| ISSN: | 2042-650X |
| Popis: | Xanthoceras sorbifolia Bunge is an edible oil tree species peculiar to China and it has long been used as a traditional medicine for enuresis in children. In this study, we investigated the active components in X. sorbifolia and eight barrigenol-type triterpenoids were isolated and identified. All the isolated compounds were tested first for H2O2-induced oxidative stress on human SH-SY5Y cells. Then Y-maze, Morris water maze, novel object recognition and passive avoidance tests were conducted to evaluate the improved effect of selected compounds with neuroprotective activity on ICV Aβ1–42 mice. Among all the tested compounds, XS-8 exhibited significant protective effects against learning and memory impairments induced by ICV-Aβ1–42. The XS-8 treatment significantly altered Aβ-induced hippocampal oxidative defense (increased MDA, nitrite and decreased SOD, glutathione) and pro-inflammatory levels (increased IL-1β and IL-18). The present study strongly suggests that X. sorbifolia is a promising plant resource for AD use and other neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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