Oscillometrically Measured Aortic Pulse Wave Velocity Reveals Asymptomatic Carotid Atherosclerosis in a Middle-Aged, Apparently Healthy Population

Autor: Thomas Kahan, Renata Bocskei, Béla Benczúr, Veronika Müller, Zsófia Lenkey, R. Husznai, Miklós Illyés, Andrea Székely, Attila Cziráki, Andras Bikov
Rok vydání: 2020
Předmět:
Adult
Carotid Artery Diseases
Male
Carotid atherosclerosis
medicine.medical_specialty
Article Subject
Cross-sectional study
Carotid arteries
Population
Pulse Wave Analysis
030204 cardiovascular system & hematology
Sensitivity and Specificity
Asymptomatic
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Vascular Stiffness
0302 clinical medicine
Oscillometry
Internal medicine
medicine.artery
medicine
Humans
030212 general & internal medicine
education
Pulse wave velocity
Aorta
Aged
Ultrasonography
Hungary
education.field_of_study
General Immunology and Microbiology
business.industry
Angiography
General Medicine
Middle Aged
Atherosclerosis
medicine.disease
Carotid Arteries
Cross-Sectional Studies
Cardiology
Arterial stiffness
Medicine
Female
medicine.symptom
business
Research Article
Zdroj: Böcskei, R M, Benczúr, B, Müller, V, Bikov, A, Székely, A, Kahan, T, Lenkey, Z, Husznai, R, Cziráki, A & Illyés, M 2020, ' Oscillometrically Measured Aortic Pulse Wave Velocity Reveals Asymptomatic Carotid Atherosclerosis in a Middle-Aged, Apparently Healthy Population ', BioMed Research International, vol. 2020, pp. 8571062 . https://doi.org/10.1155/2020/8571062
BioMed Research International
BioMed Research International, Vol 2020 (2020)
ISSN: 2314-6141
2314-6133
DOI: 10.1155/2020/8571062
Popis: Background. Asymptomatic atherosclerosis is a common entity even at young age. Studies have suggested a strong relationship between increased arterial stiffness and asymptomatic carotid atherosclerosis (ACA) in general population, particularly in those with high cardiovascular risk, but no data exist from a younger population free from recognized cardiovascular disease. Hypothesis. We hypothesized there is an association between ACA and aortic pulse wave velocity (PWVao) in middle-aged, apparently healthy, normotensive population to reveal increased cardiovascular risk. Methods. We examined the relationship between ACA and PWVao in 236 apparently healthy, asymptomatic, normotensive, middle-aged subjects (age 47 ± 8 years; 52% women). PWVao was measured with the oscillometric method (Arteriograph). ACA was assessed by carotid artery ultrasonography. Results. ACA was present in 51 subjects. Subjects with ACA were older (p<0.009), more likely to be smokers (p<0.001), and had higher systolic blood pressure (SBP, 128 ± 9 vs. 125 ± 10 mmHg, p=0.048) and PWVao (9.3 ± 1.6 vs. 7.9 ± 1.3 m/s, p<0.001) than subjects without ACA. In a stepwise logistic regression analysis, only PWVao (odds ratio: 1.88, p<0.001), smoking habit (odds ratio 3.79, p=0.003), systolic blood pressure (odds ratio 1.05, p=0.046), and diastolic blood pressure (odds ratio: 0.94, p=0.038) were independently associated with ACA. PWVao >8.3 m/s identified ACA with a 71% sensitivity, 65% specificity, 36% positive and 89% negative predictive value, 2.04 relative risk, and 4.54 odds ratio, respectively. Conclusions. PWVao measured by the Arteriograph proved to be an independent marker of ACA. Our study may reveal high CV risk, detected as increased PWVao, which according to our study is related in a very high probability to asymptomatic carotid atherosclerosis in apparently healthy, young, and middle-aged subjects.
Databáze: OpenAIRE
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