Cigarette smoking and oral microbiota in low-income and African-American populations
| Autor: | William J. Blot, Zhiheng Pei, Xiao-Ou Shu, Jirong Long, Robert M. Brucker, Seth R. Bordenstein, Zhigang Li, Qiuyin Cai, Martha J. Shrubsole, Wei Zheng, Yaohua Yang, Mark Steinwandel |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Epidemiology medicine.medical_treatment Physiology Article Cigarette Smoking law.invention 03 medical and health sciences Probiotic 0302 clinical medicine law Abundance (ecology) RNA Ribosomal 16S Lactobacillus Humans Medicine Risk factor Relative species abundance Aged 030304 developmental biology Bifidobacterium Mouth 0303 health sciences Bacteria biology Sequence Analysis RNA business.industry Microbiota Public Health Environmental and Occupational Health Middle Aged biology.organism_classification United States Black or African American Social Class 030220 oncology & carcinogenesis behavior and behavior mechanisms Income Smoking cessation Female business Cohort study |
| Zdroj: | Journal of Epidemiology and Community Health. 73:1108-1115 |
| ISSN: | 1470-2738 0143-005X |
| DOI: | 10.1136/jech-2019-212474 |
| Popis: | BackgroundCigarette smoking is a common risk factor for diseases and cancers. Oral microbiota is also associated with diseases and cancers. However, little is known about the impact of cigarette smoking on the oral microbiota, especially among ethnic minority populations.MethodsWe investigated cigarette smoking in relationship with the oral microbiota in a large population of predominately low-income and African-American participants. Mouth rinse samples were collected from 1616 participants within the Southern Community Cohort Study, including 592 current-smokers, 477 former-smokers and 547 never-smokers. Oral microbiota was profiled by 16S ribosomal RNA gene deep sequencing.ResultsCurrent-smokers showed a different overall microbial composition from former-smokers (p=6.62×10−7) and never-smokers (p=6.00×10−8). The two probiotic genera, Bifidobacterium and Lactobacillus, were enriched among current-smokers when compared with never-smokers, with Bonferroni-corrected p values (PBonferroni) of 1.28×10−4 and 5.89×10−7, respectively. The phylum Actinobacteria was also enriched in current-smokers when compared with never-smokers, with a median relative abundance of 12.35% versus 9.36%, respectively, and with a PBonferroni=9.11×10−11. In contrast, the phylum Proteobacteria was depleted in current smokers (PBonferroni=5.57×10−13), with the relative abundance being almost three times that of never-smokers (7.22%) when compared with that of current-smokers (2.47%). Multiple taxa within these two phyla showed differences in abundance/prevalence between current-smokers and never-smokers at PBonferroni ConclusionSmoking has strong impacts on oral microbial community, which was recovered after smoking cessation. |
| Databáze: | OpenAIRE |
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