Time-varying serum gradient of hepatitis B surface antigen predicts risk of relapses after off-NA therapy

Autor: Jia-Horng Kao, Ming-Shiang Wu, Yao-Chun Hsu, Jaw-Town Lin, Nai Hsuan Chien, Lein Ray Mo, Chih-Wen Lin, Chi Yang Chang, Chun Ying Wu, Tzeng Huey Yang, Chi Ming Tai, Yen-Tsung Huang
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
HBsAg
Chronic hepatitis B
Antiviral Agents
Gastroenterology
Cohort Studies
03 medical and health sciences
Hepatitis B
Chronic
0302 clinical medicine
Recurrence
Risk Factors
Interquartile range
Internal medicine
medicine
Humans
Cumulative incidence
Prospective Studies
lcsh:RC799-869
Hepatitis B surface antigen quantification
Hepatitis B Surface Antigens
Dose-Response Relationship
Drug
Time-dependent Cox proportion hazards model
business.industry
Hazard ratio
Alanine Transaminase
General Medicine
Middle Aged
Hepatology
Confidence interval
030104 developmental biology
Nucleos(t)ide analogs
Withholding Treatment
HBeAg
DNA
Viral
lcsh:Diseases of the digestive system. Gastroenterology
Female
030211 gastroenterology & hepatology
business
Research Article
Cohort study
Zdroj: BMC Gastroenterology
BMC Gastroenterology, Vol 17, Iss 1, Pp 1-7 (2017)
ISSN: 1471-230X
DOI: 10.1186/s12876-017-0697-3
Popis: Background The serum gradient of hepatitis B surface antigen (HBsAg) varies over time after cessation of nucleos(t)ide analog (NA) treatment in patients with chronic hepatitis B (CHB). The association between the time-varying HBsAg serum gradient and risk of relapse has not been elucidated. Methods This multicenter cohort study prospectively enrolled CHB patients who discontinued 3 year-NA treatment. Eligible patients were serologically negative for HBeAg and viral DNA at NA cessation. The participants (n = 140) were followed every 3 months through HBsAg quantification. Virological and clinical relapses were defined as viral DNA levels >2000 IU/mL and alanine aminotransferase (ALT) levels >80 U/mL, respectively. The association of time-varying HBsAg levels with relapses was assessed through a time-dependent Cox analysis. Results During a median follow-up of 19.9 (interquartile range [IQR], 10.6–25.3) months, virological and clinical relapses occurred in 94 and 49 patients, with a 2-year cumulative incidence of 79.2% (95% confidence interval [CI], 70.9%–86.4%) and 42.9% (95% CI, 34.1%–52.8%), respectively. The serum level of HBsAg was associated with virological (P
Databáze: OpenAIRE
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