Urinary paraben concentrations and in vitro fertilization outcomes among women from a fertility clinic
Autor: | Yu-Han Chiu, Russ Hauser, Carmen Messerlian, Mary E. Sabatini, Jennifer B. Ford, Thomas L. Toth, Lidia Mínguez-Alarcón, Paige L. Williams, Antonia M. Calafat |
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Rok vydání: | 2016 |
Předmět: |
Adult
Infertility medicine.medical_specialty Pregnancy Rate medicine.medical_treatment media_common.quotation_subject Parabens Fertility Fertilization in Vitro Urinalysis 010501 environmental sciences Hospitals General 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Risk Factors medicine Humans Embryo Implantation Prospective Studies 0105 earth and related environmental sciences media_common Butylparaben Gynecology 030219 obstetrics & reproductive medicine In vitro fertilisation Obstetrics business.industry Obstetrics and Gynecology Embryo Transfer medicine.disease Embryo transfer Pregnancy rate Treatment Outcome Reproductive Medicine chemistry Female business Live Birth Biomarkers Embryo quality Boston |
Zdroj: | Fertility and Sterility. 105:714-721 |
ISSN: | 0015-0282 |
Popis: | Objective To explore the relationship between urinary paraben concentrations and IVF outcomes among women attending an academic fertility center. Design Prospective cohort study. Setting Fertility clinic in a hospital setting. Patient(s) A total of 245 women contributing 356 IVF cycles. Intervention(s) None. Quantification of urinary concentrations of parabens by isotope-dilution tandem mass spectrometry, and assessment of clinical endpoints of IVF treatments abstracted from electronic medical records at the academic fertility center. Main Outcome Measure(s) Total and mature oocyte counts, proportion of high-quality embryos, fertilization rates, and rates of implantation, clinical pregnancy, and live births. Result(s) The geometric means of the urinary concentrations of methylparaben, propylparaben, and butylparaben in our study population were 133, 24, and 1.5 μg/L, respectively. In models adjusted for age, body mass index, race/ethnicity, smoking status, and primary infertility diagnosis, urinary methylparaben, propylparaben, and butylparaben concentrations were not associated with IVF outcomes, specifically total and mature oocyte counts, proportion of high embryo quality, and fertilization rates. Moreover, no significant associations were found between urinary paraben concentrations and rates of implantation, clinical pregnancy, and live births. Conclusion(s) Urinary paraben concentrations were not associated with IVF outcomes among women undergoing infertility treatments. |
Databáze: | OpenAIRE |
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