Fasciola hepatica infection in sheep: changes in liver metabolism
| Autor: | Carolyn A. Behm, J.C Boray, Linda M. Lenton, Fyfe L. Bygrave |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Fascioliasis Sheep Diseases Mitochondria Liver Biology Mitochondrion chemistry.chemical_compound Oxygen Consumption Cytochrome P-450 Enzyme System Reference Values Internal medicine parasitic diseases medicine Fasciola hepatica Animals Respiratory system Sheep General Veterinary Glycogen Cytochrome P450 medicine.disease biology.organism_classification Liver Glycogen Rats Endocrinology chemistry Biochemistry Liver biology.protein Microsome Microsomes Liver Phosphatidylcholines Cytochromes Liver function Infiltration (medical) |
| Zdroj: | Research in veterinary science. 61(2) |
| ISSN: | 0034-5288 |
| Popis: | Several aspects of liver function during infection with Fasciola hepatica were examined in sheep four weeks after infection and compared with the changes observed in infected rats. Previously reported respiratory abnormalities in mitochondria isolated from the left lobe of the liver of infected sheep were characterised further. Evidence is presented that the respiratory lesion is located in the mitochondrial electron transport chain and that the aberrant respiratory behaviour is not associated with an increase in nonesterified fatty acids and the depletion of mitochondrial phospholipids, as is the case in the rat. Microsomal membranes, which have also been shown to be depleted of phospholipids in the fluke-infected rat liver, showed no such changes in the sheep. However, in common with the rat, a substantial loss of cytochrome P450 was recorded in microsomes prepared from the left lobe, and the glycogen content of the left lobe was found to be less than 50 per cent of control values. No change was observed in glucose 6-phosphatase activity. All these changes were localised effects, confined to areas of fluke infiltration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect