[Interstitial lupus nephritis]
| Autor: | Bartl R, Helmchen U, Arthur Gerl, Köhler Ja, Samtleben W, Wolfgang Wilmanns |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Interstitial nephritis Prednisolone Renal function Asymptomatic Gastroenterology Diagnosis Differential Internal medicine medicine Humans Autoantibodies Proteinuria business.industry Glomerulonephritis General Medicine DNA medicine.disease Lupus Nephritis Pyuria Antibodies Antinuclear Immunoglobulin G Nephritis Interstitial medicine.symptom business Vasculitis medicine.drug |
| Zdroj: | Deutsche medizinische Wochenschrift (1946). 117(20) |
| ISSN: | 0012-0472 |
| Popis: | A 17-year old-male presented with a 6-week history of weight loss, lassitude and calf pains. On examination he was very pale. Laboratory tests showed a very high erythrocyte sedimentation rate (155 mm in the first hour), anaemia (haemoglobin 10.1 g/dl), and a raised serum creatinine of 1.54 mg/dl. Microhaematuria (5-10 erythrocytes/microliter) and pronounced pyuria (500 leucocytes/microliter) were present, but the urine was sterile and there was no increase in albumin excretion. The serum IgG was raised to 75.7 g/l, suggesting an autoimmune disorder. Anti-nuclear antibodies (titre 1 : 1920) and anti-double-stranded DNA antibodies (31 U/ml) were present, while the serum complement C4 was decreased to 0.11 g/l. Renal histology showed an interstitial nephritis without glomerular involvement, while the bone marrow showed vasculitis accompanied by a prominent plasma-cell infiltrate. A diagnosis of interstitial nephritis associated with systemic lupus erythematosus was made, with asymptomatic cardiac and hepatic involvement. Renal function recovered rapidly with prednisolone therapy (initial dose 2 mg/kg.d). While glomerulonephritis is the most common lupus-associated renal disorder, isolated interstitial nephritis may occur in some cases, often with an absence of proteinuria. |
| Databáze: | OpenAIRE |
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