Combined effect of HLA-DRB1*1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis
| Autor: | E G de la Concha, Miguel Fernández-Arquero, J.A. Campillo, Amado Salvador Peña, Rafael Arroyo, J.B.A. Crusius, E. Varela de Seijas, A. Garcia-Gonalez, C. Martin |
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| Přispěvatelé: | VU University medical center |
| Rok vydání: | 1997 |
| Předmět: |
Male
Multiple Sclerosis medicine.drug_class Sialoglycoproteins Immunology Hla drb1 1501 Severity of Illness Index Random Allocation Interleukin 1 Receptor Antagonist Gene Sex Factors Gene Frequency Recurrence Humans Immunology and Allergy Medicine Allele Gene Allele frequency Alleles Genetic heterogeneity business.industry Multiple sclerosis Receptors Interleukin-1 HLA-DR Antigens medicine.disease Receptor antagonist Interleukin 1 Receptor Antagonist Protein Relapsing remitting Neurology Spain Case-Control Studies Disease Progression Female Disease Susceptibility Neurology (clinical) Gene polymorphism business HLA-DRB1 Chains |
| Zdroj: | de la Concha, E G, Arroyo, R, Crusius, J B A, Campillo, J A, Martin, C, Varela de Seijas, E, Peña, A S, Clavería, L E & Fernandez-Arquero, M 1997, ' Combined effect of HLA-DRB1*1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis ', Journal of Neuroimmunology, vol. 80, pp. 172-178 . https://doi.org/10.1016/S0165-5728(97)00153-7 Journal of Neuroimmunology, 80, 172-178. Elsevier |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/s0165-5728(97)00153-7 |
| Popis: | Susceptibility to multiple sclerosis (MS) is associated with HLA-DRB1 * 1501. Many reports have suggested associations with other loci but these results remain unconfirmed. We studied the IL-1 receptor antagonist (IL-1ra) gene polymorphism and the HLA-DR and DQ allele frequencies by DNA-based methods in both the primary chronic progressive form (PP MS) and the relapsing/remitting form (R/R MS). The frequency of DRB1 * 1501 and IL-1ra allele 2 were significantly higher in R/R MS. Association was more marked in the female sex and in patients with benign forms of R/R MS. On the other hand DR4 subtypes carrying a Val at position 86 in the DR β chain were increased in PP MS. The present study indicates that MS is genetically heterogeneous and shows a combined effect of HLA-DR and IL-1ra genes in susceptibility to the R/R form of the disease. |
| Databáze: | OpenAIRE |
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