Do Incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence?

Autor: Blanca Oliván, Blandine Laferrère, F. Xavier Pi-Sunyer, Julio Teixeira, Mousumi Bose
Rok vydání: 2008
Předmět:
Leptin
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Gastric Bypass
Incretin
Type 2 diabetes
Gastric Inhibitory Polypeptide
medicine.disease_cause
Incretins
Article
Gastric inhibitory polypeptide
Weight loss
Glucagon-Like Peptide 1
Internal medicine
Intestine
Small
Weight Loss
medicine
Glucose homeostasis
Animals
Homeostasis
Humans
Peptide YY
skin and connective tissue diseases
Randomized Controlled Trials as Topic
Nutrition and Dietetics
Evidence-Based Medicine
Gastric emptying
Gastric bypass surgery
business.industry
Insulin
digestive
oral
and skin physiology
Remission Induction
Gluconeogenesis
medicine.disease
Ghrelin
Obesity
Morbid
Endocrinology
Glucose
Diabetes Mellitus
Type 2
Gastric Emptying
Liver
Surgery
sense organs
medicine.symptom
business
Zdroj: Obesity surgery. 19(2)
ISSN: 0960-8923
Popis: Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 diabetes (T2DM). The mechanisms by which this remission occurs are unclear. Besides weight loss and caloric restriction, the changes in gut hormones that occur after GBP are increasingly gaining recognition as key players in glucose control. Incretins are gut peptides that stimulate insulin secretion postprandially; the levels of these hormones, particularly glucagon-like peptide-1, increase after GBP in response to nutrient stimulation. Whether these changes are causal to changes in glucose homeostasis remain to be determined. The purpose of this review is to assess the evidence on incretin changes and T2DM remission after GBP, and the possible mechanisms by which these changes occur. Our goals are to provide a thorough update on this field of research so that recommendations for future research and criteria for bariatric surgery can be evaluated.
Databáze: OpenAIRE
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