Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment
| Autor: | Andrew Hollands, Victor Nizet, Josh Olson, Emma Leire, Hart Isaacs |
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| Rok vydání: | 2013 |
| Předmět: |
Inflammation
Innate immune system business.industry medicine.medical_treatment Clinical Biochemistry Short Report Regulator Cell Biology Hypoxia (medical) Hypoxia-inducible factor Cell biology HIF1A Cytokine medicine.anatomical_structure Hypoxia-inducible factors Neutrophil recruitment Immunology medicine HIF medicine.symptom business Keratinocyte |
| Zdroj: | Leire, Emma; Olson, Josh; Isaacs, Hart; Nizet, Victor; & Hollands, Andrew. (2013). Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment. Journal of Inflammation, 10(1), 28. doi: http://dx.doi.org/10.1186/1476-9255-10-28. Retrieved from: http://www.escholarship.org/uc/item/9dj5b251 Journal of Inflammation (London, England) |
| ISSN: | 1476-9255 |
| Popis: | Background Hypoxia inducible factor-1 (HIF-1) is a major regulator of the cellular adaption to low oxygen stress and the innate immune function of myeloid cells. Treatment with the novel HIF-1 stabilizing drug AKB-4924 has been shown to enhance the bactericidal activity of keratinocytes as well as phagocytic cells. In this study, we sought to investigate the effect of pharmacological boosting of HIF-1 with AKB-4924 in keratinocytes and their contribution to the innate immune response. Findings Treatment with the novel HIF-1 stabilizing drug AKB-4924 can increase keratinocyte production of pro-inflammatory cytokines in vitro and enhance neutrophil recruitment in vivo. Conclusions HIF plays an important role in cytokine production by keratinocytes and in neutrophil recruitment to the skin. The HIF-boosting drug AKB-4924 has the potential to enhance the immune response even in the complex environment of bacterial skin infections. |
| Databáze: | OpenAIRE |
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