Bioassay of 2, 4, 5-trichlorophenoxyacetic acid for carcinogenicity in mice
| Autor: | J Imbert, G Rudali, I Muranyi-Kovacs |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Carcinoma Hepatocellular Lung Neoplasms Mice Inbred Strains Biology Dioxins medicine.disease_cause Mice chemistry.chemical_compound Sex Factors Inbred strain Oral administration Internal medicine 2 4 5-Trichlorophenoxyacetic acid medicine Animals Neoplasm Bioassay Carcinogen Mice Inbred C3H Leukemia Experimental 2 4 5-Trichlorophenoxyacetic Acid Liver Neoplasms Neoplasms Experimental medicine.disease Leukemia Endocrinology Oncology chemistry Female Carcinogenesis Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1976.100 |
| Popis: | Adult mice of strains C3Hf and XVII/G received 2, 4, 5-T by continuous oral administration (80 ppm in the diet). The 2, 4, 5-T preparation contained less than 0-05 ppm of dioxins. In 2, 4, 5-T -treated C3Hf mice a significant increase in the incidence of neoplastic lesions was found. No significant difference was found in the XVII/G strain between the treated and control mice. Rare forms of tumours, which were not observed in the controls, were present in the 2, 4, 5-t -treated C3Hf mice. |
| Databáze: | OpenAIRE |
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