| Autor: |
Ernestina Santos, João Moura, Raquel Samões, Ana Paula Sousa, Teresa Mendonça, Pedro Abreu, Joana Guimarães, Inês Correia, Joao Durães, Lívia Sousa, João Ferreira, João de Sá, Filipa Sousa, Marta Sequeira, Ana Sofia Correia, Ana Luísa André, Carlos Basílio, Marta Arenga, Inês Brás Marques, Sandra Perdigão, Ivânia Alves, Mariana Santos, Vasco Salgado, Adelaide Palos, Rui Guerreiro, Luís Isidoro, Daniela Boleixa, Paula Carneiro, Esmeralda Neves, Ana Martins Silva, Guilherme Gonçalves, Maria José Sá |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Introduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMOSD study we analyzed the clinical/demographic characteristics of the LONMOSD. Results: From the 180 Portuguese patients 45 had disease onset after 50 years old, 80% were female. 23 had anti-AQP4 antibodies (51.1%), 13 anti-MOG antibodies (28.9%) and 9 were double seronegative (20.0%). The most common presenting phenotypes in LONMOSD were transverse myelitis (53.3%) and optic neuritis (26.7%), without difference from EONMOSD (p = 0.074). The mean EDSS for LONMOSD was 6.0 (SD=2.8), after a mean follow-up time of 4.58 (SD=4.47) years, which was significantly greater than the mean EDSS of EONMOSD (3.25, SD=1.80)(p = 0.022). Anti-AQP4 antibodies positive LONMOSD patients had increased disability compared to anti-MOG antibodies positive LONMOSD (p = 0.022). The survival analysis showed a reduced time to use a cane for LONMOSD, irrespective of serostatus (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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