| Autor: |
Jia Sheng, Jing Zhang, Qiang Luo, Yiqing Chen, Chun Yang, Ruixue Cui, Yunshan Cheng, Jianhua Gan, Fusheng Shen, Jixi Li, Jinbiao Ma, Phensinee Haruehanroengra, Qingqing Yao, Hehua Liu, Baixing Wu |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Angewandte Chemie International Edition. 56:9430-9434 |
| ISSN: |
1433-7851 |
| DOI: |
10.1002/anie.201704891 |
| Popis: |
Metal-mediated base pairs have been extensively utilized in many research fields, including genetic-code extension, novel therapeutics development, and nanodevice design. Compared to other cations, AgI is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-AgI -C pairs and the first reported G-AgI -G pair in a short 8mer DNA strand. This structure not only provides detailed insight into these AgI -mediated base-pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by heavy-metal ions, thus further contributing to the structural diversity of DNA. This unique complex structure is highly sequence-dependent, thus implying functional potentials as a new DNA aptamer that can bind and recognize silver ions. These results not only advance our understanding of the interactions between AgI and nucleobases, but also provide a unique structural component for the rational design of new DNA nanodevices. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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