Restoring both continence and micturition after chronic spinal cord injury by pudendal neuromodulation
| Autor: | James R. Roppolo, Changfeng Tai, Jicheng Wang, William C. de Groat, Katherine Shapiro, Kody Armann, Zhaoxia Wang, Bing Shen, Wenbin Guo |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Urinary system Pudendal nerve media_common.quotation_subject Urinary Bladder Urination Stimulation Electric Stimulation Therapy Thoracic Vertebrae 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Medicine Animals Spinal cord injury Spinal Cord Injuries media_common CATS business.industry Urethral sphincter medicine.disease Neuromodulation (medicine) Pudendal Nerve 030104 developmental biology Urinary Incontinence Neurology Anesthesia Cats Female business 030217 neurology & neurosurgery |
| Zdroj: | Experimental neurology. 340 |
| ISSN: | 1090-2430 |
| Popis: | Neurogenic bladder management after spinal cord injury (SCI) is very challenging. Daily urethral catheterization is most commonly used to empty the bladder, which causes frequent infections of the lower urinary tract. This study reports a novel idea to restore both continence and micturition after SCI by an implantable pudendal nerve stimulator (PNS). The PNS was surgically implanted in four cats with complete SCI at T9-T10 spinal level and tested weekly for 13–14 weeks under awake conditions. These chronic SCI cats consistently exhibited large residual bladder volumes (average 40–50 ml) due to their inability to void efficiently, while urine leakage also occurred frequently. The PNS which consisted of stimulating the pudendal nerve at 20–30 Hz to trigger a spinal reflex bladder contraction and at the same time blocking the pudendal nerves bilaterally with 10 kHz stimulation to relax the external urethral sphincter and reduce the urethral outlet resistance successfully induced highly efficient (average 80–100%), low pressure ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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