Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study

Autor: Federico Pulido, Ferran Torres, ALBERTO VENTOSO, Valentín Cuervas-Mons, Pedro Lopez Cillero, Víctor Asensi Álvarez, Carolina Almohalla, Rosa JORBA, Ramon Charco, José Antonio Pons-Miñano, Carme Baliellas, Pilar Barrera Baena, Rafael Bañares, Isabel Campos Varela, Gonzalo Crespo, Montse Tuset, M. Trinidad Serrano Aulló, Manuel Rodriguez, Josep Mallolas Masferrer, Antonio Rivero Román, Santos Del Campo, Constantino Fondevila, Pilar Martín-Dávila, Juan González-García, Carlos Cervera, Victor Manuel Vargas Blasco, Oscar Len, María Pilar Alonso García, Jesus Fortun, MARIA VICTORIA AGUILERA SANCHO-TELLO, Gloria Sanchez Antolin, Montserrat Laguno Centeno, José Miguel Cisneros, Jorge Calvo, Jordi Carratala, Xavier Forns, Rafael Rubio García, Antonio Rivero, Asunción Moreno Camacho, Elisa Cordero, Xavier Xiol, Emilio Fábrega
Rok vydání: 2018
Předmět:
Male
Human immunodeficiency virus (HIV)
HIV Infections
Hepacivirus
030230 surgery
medicine.disease_cause
DIRECT ACTING ANTIVIRALS
human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) [infection and infectious agents-viral]
Gastroenterology
chemistry.chemical_compound
0302 clinical medicine
Recurrence
Genotype
Immunology and Allergy
Medicine
Pharmacology (medical)
Prospective Studies
liver transplantation
Coinfection
virus diseases
Hepatitis C
Middle Aged
Prognosis
practice
human immunodeficiency virus (HIV) [infection and infectious agentsviral]
hepatitis C [infection and infectious agentsviral]
Tolerability
Drug Therapy
Combination
Female
030211 gastroenterology & hepatology
Cohort study
medicine.medical_specialty
Hepatitis C virus
clinical research/practice
Antiviral Agents
03 medical and health sciences
Internal medicine
Humans
acquired immunodeficiency syndrome (AIDS)
Transplantation
business.industry
Ribavirin
HIV
medicine.disease
Transplant Recipients
digestive system diseases
Liver Transplantation
clinical research
chemistry
hepatology
hepatitis C [infection and infectious agents-viral]
business
liver transplantation/hepatology
Follow-Up Studies
Zdroj: AMERICAN JOURNAL OF TRANSPLANTATION
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
ISSN: 1600-6135
DOI: 10.1111/ajt.14996
Popis: Direct-acting antivirals have proved to be highly efficacious and safe in monoinfected liver transplant (LT) recipients who experience recurrence of hepatitis C virus (HCV) infection. However, there is a lack of data on effectiveness and tolerability of these regimens in HCV/HIV-coinfected patients who experience recurrence of HCV infection after LT. In this prospective, multicenter cohort study, the outcomes of 47 HCV/HIV-coinfected LT patients who received DAA therapy (with or without ribavirin [RBV]) were compared with those of a matched cohort of 148 HCV-monoinfected LT recipients who received similar treatment. Baseline characteristics were similar in both groups. HCV/HIV-coinfected patients had a median (IQR) CD4 T-cell count of 366 (256-467) cells/mu L. HIV-RNA was
Databáze: OpenAIRE
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