Intercellular adhesion molecule, plasma adiponectin and albuminuria in type 2 diabetic patients
| Autor: | Ina Maria Kacso, Crina Rusu, Mirela Gherman Caprioara, Rodica Rahaian, Cosmina Ioana Bondor, Alina Ramona Lenghel |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Intercellular Adhesion Molecule-1 Renal function Type 2 diabetes Kidney Function Tests chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Albuminuria Humans Diabetic Nephropathies Chemokine CCL2 Aged Aged 80 and over Inflammation Creatinine Adiponectin business.industry General Medicine Middle Aged medicine.disease Intercellular adhesion molecule chemistry Diabetes Mellitus Type 2 Female medicine.symptom business |
| Zdroj: | Diabetes research and clinical practice. 95(1) |
| ISSN: | 1872-8227 |
| Popis: | Our study addressed the influence of early inflammatory stages of diabetic kidney disease: leukocyte adhesion and monocyte activation (as assessed by intercellular leukocyte adhesion molecule-ICAM-1 and monocyte chemoatractant protein-MCP-1) on the degree of albuminuria. Plasma levels of adiponectin, a possible anti-inflammatory counteracting mechanism, were also studied in correlation to the above-mentioned cytokines.79 consecutive type 2 diabetic outpatients and 46 controls were included. Routine laboratory analysis, urinary albumin to creatinine ratio (uACR), plasma adiponectin, plasma ICAM-1 and urinary MPC-1 were assessed.In multiple regression ICAM-1 (p=0.004) and adiponectin (p=0.04) were the main determinants of uACR. Plasma adiponectin positively correlated to ICAM-1 (p=0.03, r=0.24). In albuminuric patients (uACR ≥30 mg/g) plasma adiponectin was significantly higher compared to normoalbuminuric ones (uACR30 mg/g). In albuminuric patients the main determinants of uACR were plasma ICAM-1 and adiponectin. In multiple regression ICAM-1 is the only one that retains statistical significance (p=0.02). Urinary MCP-1 did not correlate to uACR.In our type 2 diabetic patients, plasma levels of ICAM-1 and adiponectin are predictive for albuminuria. Urinary MCP-1 does not correlated to uACR. Plasma adiponectin positively correlates to adhesion molecule ICAM-1 in our cohort. |
| Databáze: | OpenAIRE |
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