Validation of Resting Diastolic Pressure Ratio Calculated by a Novel Algorithm and Its Correlation With Distal Coronary Artery Pressure to Aortic Pressure, Instantaneous Wave–Free Ratio, and Fractional Flow Reserve
| Autor: | Jurgen Ligthart, Isabella Kardys, Jeroen Wilschut, Joost Daemen, Roberto Diletti, Karen Witberg, Kaneshka Masdjedi, Nicolas M. Van Mieghem, Laurens J.C. van Zandvoort, Peter de Jaegere, Felix Zijlstra, Miguel E. Lemmert, Frits Mastik |
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| Přispěvatelé: | Cardiology |
| Rok vydání: | 2018 |
| Předmět: |
Male
Cardiac Catheterization Time Factors Software Validation Proprietary software Coronary Artery Disease Fractional flow reserve 030204 cardiovascular system & hematology Coronary Angiography Cardiac Catheters Correlation 03 medical and health sciences 0302 clinical medicine Software Diastole Predictive Value of Tests Transducers Pressure medicine Humans Arterial Pressure 030212 general & internal medicine Instantaneous wave-free ratio Aorta Aged Retrospective Studies Aged 80 and over business.industry Reproducibility of Results Middle Aged Coronary Vessels Fractional Flow Reserve Myocardial medicine.anatomical_structure Blood pressure Aortic pressure Feasibility Studies Female Cardiology and Cardiovascular Medicine business Algorithm Algorithms Artery |
| Zdroj: | Circulation-cardiovascular interventions, 11(12):e006911. Lippincott Williams & Wilkins |
| ISSN: | 1941-7632 1941-7640 |
| Popis: | Background: Instantaneous wave–free ratio (iFR) offers a reliable non–hyperemic assessment of coronary physiology but requires dedicated proprietary software with a fully automated algorithm. We hypothesized that dPR (diastolic pressure ratio), calculated with novel universal software, has a strong correlation with iFR, similar diagnostic accuracy relative to resting distal coronary artery pressure/aortic pressure and fractional flow reserve (FFR). Methods and Results: The dPR study is an observational, retrospective, single-center cohort study including patients who underwent iFR or FFR. Dedicated software was used to calculate the dPR from Digital Imaging and Communications in Medicine (DICOM) pressure waveforms. The flat period on the pressure difference between sample (dP) to the time difference between the same sample points (dt) signal was used to detect automatically the period, where the resistance is low and constant, and to calculate the dPR, which is an average over 5 consecutive heartbeats. The software was validated by correlating iFR results with dPR. Software validation was done by comparing 78 iFR measurements in 44 patients who underwent iFR. Mean iFR and dPR were 0.91±0.10 and 0.92±0.10, respectively, with a significant linear correlation ( R =0.997; P R =0.77; P Conclusions: dPR, calculated by a novel validated software tool, showed a strong linear correlation with iFR. dPR correlated well with FFR with a good diagnostic accuracy to identify positive FFR. |
| Databáze: | OpenAIRE |
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