Analysis of pulmonary nodules in patients with high-grade soft tissue sarcomas
| Autor: | Keitaro Mizumoto, Takao Matsubara, Miki Matsusaka, Mayuko Mori, Kunihiro Asanuma, Akihiro Sudo, Tomoya Yoshizaki, Tomoki Nakamura, Akihiko Matsumine |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Lung Neoplasms lcsh:Medicine Computed tomography Soft Tissue Neoplasms Pathology and Laboratory Medicine Lung and Intrathoracic Tumors 030218 nuclear medicine & medical imaging Metastasis Diagnostic Radiology 0302 clinical medicine Mathematical and Statistical Techniques Basic Cancer Research Medicine and Health Sciences lcsh:Science Child Tomography Aged 80 and over Multidisciplinary medicine.diagnostic_test Radiology and Imaging Sarcomas Soft tissue Sarcoma Middle Aged Oncology 030220 oncology & carcinogenesis Physical Sciences Female Radiology medicine.symptom Statistics (Mathematics) Research Article Adult medicine.medical_specialty Soft Tissue Neoplasm Adolescent Imaging Techniques Neuroimaging Surgical and Invasive Medical Procedures Research and Analysis Methods 03 medical and health sciences Signs and Symptoms Diagnostic Medicine medicine Cancer Detection and Diagnosis Humans In patient Statistical Methods Lung cancer Aged Surgical Resection business.industry lcsh:R Biology and Life Sciences Cancers and Neoplasms Nodule (medicine) medicine.disease Computed Axial Tomography Multivariate Analysis Lesions lcsh:Q business Tomography X-Ray Computed Mathematics Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 2, p e0172148 (2017) |
| ISSN: | 1932-6203 |
| Popis: | Nowadays, small pulmonary nodules are easily detectable in patients with soft tissue sarcomas (STSs) because of highly improved computed tomography (CT) technologies. The purpose of this study was to determine the frequency and significance of the pulmonary nodules detected by CT in high-grade STS patients. 124 patients with high-grade STS were retrospectively reviewed. There were 72 males (57%) and 52 females (43%). Patients' average age was 61 years (median (quartiles) 66 years (48-75), range 8-94 years). Pulmonary nodules were detected in 49 (39.5%) of 124 patients by CT scanning at first presentation. Of 49 patients with nodules at first presentation, 34 (69.4%) had benign lesions, and 13 (26.5%) had metastatic nodules. One patient (2%) had primary lung cancer and the remaining one with one nodule could not be definitively diagnosed due to a short follow-up time. 30 patients (24.1%) of 124 patients developed pulmonary nodules during their clinical progression. Seven (23.3%) had benign lesions, whereas 21 (70%) had metastatic lesions. Primary lung cancer was detected in two patients (6.7%). The size and timing of detection of a pulmonary nodule significantly affected the final clinical diagnosisby multivariate analysis. We conclude that pulmonary nodules can be detected highly frequently in patients with high-grade STSs because of improved CT technologies. Careful follow-up is needed if nodules are detected after initial treatment or during the clinical course of the disease. |
| Databáze: | OpenAIRE |
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