Glycemic modulation of tumor tolerance in a mouse model of breast cancer
| Autor: | Edward E. Hamel, Susan M. Kozawa, George A. Santisteban, John T.A. Ely, David H. Read |
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| Rok vydání: | 1985 |
| Předmět: |
Blood Glucose
Cellular immunity medicine.medical_specialty Mammary Neoplasms Biophysics Ascorbic Acid Malignancy Biochemistry Mice Breast cancer Phagocytosis Internal medicine Leukocytes medicine Animals Melanoma Molecular Biology Glycemic Mice Inbred BALB C Mammary tumor business.industry Mammary Neoplasms Experimental Cancer Cell Biology medicine.disease Disease Models Animal Endocrinology Female business Human breast |
| Zdroj: | Biochemical and Biophysical Research Communications. 132:1174-1179 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(85)91930-8 |
| Popis: | Marked sensitivity of tumor tolerance to blood glucose level is demonstrated in a mouse model of human breast cancer. A theory is cited that explains the high association of hyperglycemia with malignancy, especially breast cancer, via glycemic modulation of cellular immunity. Three groups of BALB/C mice were injected with an aggressive mammary tumor and placed on three dietary regimens designed to produce three different glycemic levels. Mortalities 70 days after injection were 16 of 24 hyperglycemic mice, 8 of 24 normoglycemic, and 1 of 20 hypoglycemic (chi-square p less than .005). Taken together with other experiments and human data discussed briefly, this result suggests that glycemic modulation of tumor tolerance should be evaluated in human trials. |
| Databáze: | OpenAIRE |
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