Temperature-responsive copolymers without compositional drift by RAFT copolymerization of 2-(acryloyloxy)ethyl trimethylammonium chloride and 2-(diethylamino)ethyl acrylate
| Autor: | Carlos Baleizão, Arnaud Favier, José Paulo S. Farinha, Marie-Thérèse Charreyre, Ana Sofia Rodrigues |
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| Přispěvatelé: | Laboratoire Joliot Curie, École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS), Universidade de Lisboa (ULISBOA), Ingénierie des Matériaux Polymères (IMP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS), Universidade de Lisboa = University of Lisbon (ULISBOA), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Polymers and Plastics
Chemistry Comonomer Organic Chemistry Bioengineering 02 engineering and technology Raft 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Chloride 0104 chemical sciences chemistry.chemical_compound Monomer [CHIM.POLY]Chemical Sciences/Polymers Polymer chemistry medicine Proton NMR Copolymer Ethyl acrylate Reversible addition−fragmentation chain-transfer polymerization 0210 nano-technology medicine.drug |
| Zdroj: | Polymer Chemistry Polymer Chemistry, Royal Society of Chemistry-RSC, 2019, 10 (17), pp.2106-2116. ⟨10.1039/c8py01615a⟩ Polymer Chemistry, 2019, 10 (17), pp.2106-2116. ⟨10.1039/c8py01615a⟩ |
| ISSN: | 1759-9954 1759-9962 |
| DOI: | 10.1039/c8py01615a⟩ |
| Popis: | International audience; We prepared novel temperature and pH responsive copolymers of [2-(acryloyloxy)ethyl] trimethylammonium chloride (AEtMACl) and 2-(diethylamino)ethyl acrylate (DEAEA) by RAFT polymerization. Such copolymers show a volume phase transition temperature that explains the excellent performance of hydrogels of the same monomers, selected among 600 different monomer combinations, to release cultured stem cells using only a mild temperature stimulus (R. Zhang, H. K. Mjoseng, M. A. Hoeve, N. G. Bauer, S. Pells, R. Besseling, S. Velugotla, G. Tourniaire, R. E. B. Kishen, Y. Tsenkin, C. Armit, C. R. E. Duffy, M. Helfen, F. Edenhofer, P. A. Sousa and M. Bradley, Nat. Commun., 2013, 1–10). We carried out a thorough investigation of the (co)polymerization kinetics of AEtMACl and protonated DEAEA in ethanol, and proposed convenient and reliable methods to follow the conversion of these two monomers by 1H NMR. Interestingly, for a very large range of feed compositions, the cumulative copolymer composition versus global conversion plots indicated that there was almost no compositional drift, corresponding to apparent reactivity ratios of about 1. Therefore, the copolymer has the same composition as the comonomer feed, regardless of both conversion and initial molar ratio. This rare situation enables the preparation of a variety of copolymer chains with highly homogeneous composition and microstructure, offering excellent prospects for the use of these materials as triggers in controlled release applications. |
| Databáze: | OpenAIRE |
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