Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer
| Autor: | Muthusamy Thangaraju, Vadivel Ganapathy, Yangzom D. Bhutia, Puttur D. Prasad, Sabarish Ramachandran, Jaya P. Gnana-Prakasam, Ellappan Babu |
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| Rok vydání: | 2015 |
| Předmět: |
Commentary Articles
medicine.medical_specialty Amino Acid Transport Systems Commentary Article cancer metabolism Estrogen receptor Biology Plasma Membrane Neurotransmitter Transport Proteins Biochemistry amino acid transporter Mice Drug Delivery Systems SLC6A14 (ATB0 +) Internal medicine medicine Animals Amino acid transporter Molecular Biology PI3K/AKT/mTOR pathway Cell Proliferation Mice Knockout chemistry.chemical_classification Messenger RNA TOR Serine-Threonine Kinases RPTOR Mammary Neoplasms Experimental Transporter Cell Biology targeted therapy Neoplasm Proteins Amino acid oestrogen receptor-positive (ER+) breast cancer Endocrinology chemistry Knockout mouse Cancer research Female Gene Deletion Signal Transduction |
| Zdroj: | Biochemical Journal |
| ISSN: | 1470-8728 0264-6021 |
| Popis: | The cancer-specific nutrient transporter, SLC6A14, could be a means to target cancer metabolism as described by Babu et al. in this issue. Rapidly proliferating cancer cells increase flux through anabolic pathways to build the mass necessary to support cell division. Imported amino acids and glucose lie at the apex of the anabolic pyramid. Consistent with this, elevated expression of nutrient transporter proteins is characteristic of aggressive and highly malignant cancers. Because tumour cells are more dependent than their normal neighbours on accelerated nutrient import, these up-regulated transporters could be excellent targets for selective anti-cancer therapies. A study by Babu et al. in a recent issue of the Biochemical Journal definitively shows that SLC6A14 (where SLC is solute carrier) is one such cancer-specific amino acid transporter. Although mice completely lacking SLC6A14 are viable and exhibit normal mammary gland development, these animals are highly resistant to mammary tumour initiation and progression driven by potent oncogenes. Because SLC6A14 is essential for tumour growth yet dispensable for normal development and tissue maintenance, small molecules that block amino acid import through this transporter could be effective and selective anti-cancer agents, particularly as components of rational drug combinations. |
| Databáze: | OpenAIRE |
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