Clinical Features of Systemic Lupus Erythematosus in Tunisian Males
| Autor: | M.S. Hamdi, Faida Ajili, Nadia Ben Abdelhafidh, Gueddiche Nour, Arfaoui Bilel, Tayssir Ben Achour, S Mezri, Sameh Sayhi, Bassem Louzir |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Poor prognosis Tunisia Disease Severity of Illness Index 03 medical and health sciences Sex Factors 0302 clinical medicine Rheumatology Internal medicine medicine Humans Lupus Erythematosus Systemic 030212 general & internal medicine Retrospective Studies 030203 arthritis & rheumatology Systemic lupus erythematosus biology business.industry Significant difference Middle Aged Prognosis medicine.disease Treatment Outcome Peripheral neuropathy Antirheumatic Agents Joint damage biology.protein Female Symptom Assessment Antibody business Serositis Hydroxychloroquine |
| Zdroj: | Current Rheumatology Reviews. 16:139-142 |
| ISSN: | 1573-3971 |
| Popis: | Purpose: Systemic Lupus Erythematosus (SLE) in males is rare. Clinical and biological features, as well as, the outcome may differ comparatively to female patients. The purpose of our study is to define these clinical and biological features in Tunisian male patients presenting SLE. Methods: A mono-centric, retrospective and descriptive study of 96 patients followed for SLE out of which 21 are males. A comparative study was then performed between male and female patients groups. Results: Sex-ratio female/male was 3.6/1, the average age at diagnosis of SLE was 37.8±14 years. The most frequently noted clinical manifestations were: skin involvement (81%), renal involvement (71.4%) and joint damage (66.7). We observed a significant difference in clinical features between male and female patients (21 males and 76 females): renal failure (52% vs. 71.4%), serositis (23.8% vs. 2.7%), peripheral neuropathy (19% vs. 4%) and lung interstitial disease (14.3% vs. 1.3%). No significant difference was found in the positivity of serum antibodies between the two groups. Fifteen male patients (71.4%) had a SLEDAI score greater than or equal to 11, referring to high/very high disease activity. Out of the 32 patients who developed infectious complications during the course of the disease, 11 were male (52.4% of males). Concerning the male group, complete remission was observed in 10 patients (47.6%), while 10 others presented persistent sequella. We observed one death in the male group secondary to infective acute respiratory failure. Conclusion: SLE in male patients is rare and associated with poor prognosis. Disparity was observed in clinical and biological features as well as outcome in the different studies. In our study, we concluded that male lupus is more severe. |
| Databáze: | OpenAIRE |
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