Designing, structural determination and biological effects of rifaximin loaded chitosan- carboxymethyl chitosan nanogel
| Autor: | Chao Li, Ali Dawood, Kaixiang Zhou, Muhammad Kashif Maa, Shuyu Xie, Dongmei Chen, Samah Attia Algharib, Saeed Ahmed, Kuiyu Meng, Lingli Huang |
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| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Bioadhesive Nanogels 02 engineering and technology 010402 general chemistry 01 natural sciences Rifaximin Chitosan chemistry.chemical_compound Drug Delivery Systems Microscopy Electron Transmission X-Ray Diffraction Spectroscopy Fourier Transform Infrared Materials Chemistry medicine Solubility Particle Size Organic Chemistry Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 0104 chemical sciences Anti-Bacterial Agents Drug Liberation chemistry Permeability (electromagnetism) Drug Design Drug delivery Triton X-100 Swelling medicine.symptom 0210 nano-technology Nuclear chemistry Nanogel |
| Zdroj: | Carbohydrate polymers. 248 |
| ISSN: | 1879-1344 |
| Popis: | Due to the poor solubility and permeability of rifaximin (RFX), it is not effective against intracellular pathogens although it shows strong activity against most bacteria. To develop an effective mucoadhesive drug delivery system with a targeted release in bacterial infection site, RFX-loaded chitosan (CS)/carboxymethyl-chitosan (CMCS) nanogel was designed and systematically evaluated. FTIR, DSC, and XRD demonstrated that the nanogel was formed by interactions between the positively charged NH3+ on CS and CMCS, and the negatively charged COO on CMCS. RFX was encapsulated into the optimized nanogel in amorphous form. The nanogel was a uniform spherical shape with a mean diameter of 171.07 nm. It had excellent sustained release, strong mucin binding ability, and pH-responsive properties of quicker swelling and release at acidic pH. It showed low hemolytic ratio and high antioxidant activity. The present investigation indicated that the CS-nanogel could be potentially used as a promising bacterial responsiveness drug delivery system. |
| Databáze: | OpenAIRE |
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