Individual data meta-analysis for the study of survival after pulmonary metastasectomy in colorectal cancer patients: A history of resected liver metastases worsens the prognosis

Autor: Pascal Gervaz, Víctor Abraira, Kazuhiro Watanabe, Pierre Emmanuel Falcoz, Takashi Matsui, Michel Gonzalez, Maria G. Zampino, Sukki Cho, Arlene M. Correa, Samer Salah, Jose I. Emparanza, José R. Jarabo, Francesco Ardissone, Tomohiko Iida, Jon Zabaleta
Rok vydání: 2018
Předmět:
Male
Oncology
medicine.medical_specialty
Lung Neoplasms
Multivariate analysis
Colorectal cancer
030204 cardiovascular system & hematology
Disease-Free Survival
Metastasis
03 medical and health sciences
0302 clinical medicine
Carcinoembryonic antigen
Risk Factors
Internal medicine
medicine
Hepatectomy
Humans
Pneumonectomy
Aged
Proportional Hazards Models
Lung
biology
Thoracic Surgery
Video-Assisted
business.industry
Liver Neoplasms
Hazard ratio
Metastasectomy
Margins of Excision
General Medicine
Middle Aged
Prognosis
medicine.disease
Carcinoembryonic Antigen
Tumor Burden
Survival Rate
medicine.anatomical_structure
030220 oncology & carcinogenesis
Meta-analysis
biology.protein
Female
Surgery
Lymph Nodes
Colorectal Neoplasms
business
Lung Metastasis Liver Colorectal cancer Individual data meta-analysis Survival
Zdroj: European Journal of Surgical Oncology. 44:1006-1012
ISSN: 0748-7983
DOI: 10.1016/j.ejso.2018.03.011
Popis: OBJECTIVES To assess the impact of a history of liver metastases on survival in patients undergoing surgery for lung metastases from colorectal carcinoma. METHODS We reviewed recent studies identified by searching MEDLINE and EMBASE using the Ovid interface, with the following search terms: lung metastasectomy, pulmonary metastasectomy, lung metastases and lung metastasis, supplemented by manual searching. Inclusion criteria were that the research concerned patients with lung metastases from colorectal cancer undergoing surgery with curative intent, and had been published between 2007 and 2014. Exclusion criteria were that the paper was a review, concerned surgical techniques themselves (without follow-up), and included patients treated non-surgically. Using Stata 14, we performed aggregate data and individual data meta-analysis using random-effect and Cox multilevel models respectively. RESULTS We collected data on 3501 patients from 17 studies. The overall median survival was 43 months. In aggregate data meta-analysis, the hazard ratio for patients with previous liver metastases was 1.19 (95% CI 0.90-1.47), with low heterogeneity (I2 4.3%). In individual data meta-analysis, the hazard ratio for these patients was 1.37 (95% CI 1.14-1.64; p
Databáze: OpenAIRE
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