A useful marker in the assessment of remission and activation of disease in patients with rheumatoid arthritis: Serum human neutrophil peptides 1-3

Autor:	Mehtap Bozkurt, Abdullah Dagli, Mehmet Okçu, Kemal Nas, Pelin Oktayoglu, Mehmet Caglayan, Nuriye Mete
Přispěvatelé:	Kırşehir Ahi Evran Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri, Fiziksel Tıp ve Rehabilitasyon ABD
Rok vydání:	2018
Předmět:	0301 basic medicine Adult Male medicine.medical_specialty alpha-Defensins Physical Therapy Sports Therapy and Rehabilitation Disease human neutrophil peptides Pathogenesis Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Internal medicine Surveys and Questionnaires Medicine Outpatient clinic Humans Orthopedics and Sports Medicine Rheumatoid arthritis 030203 arthritis & rheumatology business.industry Rehabilitation Middle Aged medicine.disease Pathophysiology Rheumatology 030104 developmental biology Nottingham Health Profile Etiology Female business disease activity Biomarkers
Zdroj:	Journal of back and musculoskeletal rehabilitation. 31(6)
ISSN:	1878-6324
Popis:	WOS: 000460934000017 PubMed ID: 29991120 AIM: Rheumatoid arthritis (RA) is a chronic disease of unknown etiology. Various cellular and molecular immunological factors are involved in the pathophysiology of RA. Recent studies suggest that neutrophils and alpha-defensins released from the neutrophils assume significant roles in the pathogenesis of RA. The aim of this study was to investigate the potential association between serum alpha-defensin levels and disease activity, functional status, radiological damage and several laboratory parameters in patients with RA. MATERIALS AND METHODS: A total of 42 patients with established RA who presented to the outpatient clinics of rheumatology of Dicle University Hospital and 38 healthy control subjects were included in this study. Disease activity was assessed by using the Disease Activity Scale 28 (DAS28). Quality of life was assessed by using the Rheumatoid Arthritis Quality of Life (RAQoL) Questionnaire and the Nottingham Health Profile (NHP). Functional status was assessed by using the Stanford Health Assessment Questionnaire (HAQ). Laboratory examinations included the following tests: CBC, ESH, CRP, and HNP 1-3. RESULTS: Patients with an active disease exhibited higher HNP 1-3 levels compared to patients in remission. At a cut off value of 708 pg/ml, sensitivity and specificity of the tests for HNP 1-3 were 72% and 70.6%, respectively. CONCLUSION: In the present study, patients with an active disease had significantly higher serum HNP 1-3 levels compared to patients in remission. In this respect, serum HNP 1-3 can be a useful marker in the assessment of disease activity and remission in patients with RA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b7864cf53e8d1a61f5e909b062aca5 https://pubmed.ncbi.nlm.nih.gov/29991120 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.