Prognostic impact of serum procalcitonin in non-small cell lung cancer
| Autor: | Akihito Kubo, Masaya Fukami, Toshio Kato, Mika Sato, Hiroyuki Tanaka, Wataru Ohashi, Satoru Ito, Toshiyuki Yonezawa, Yasutaka Kato, Etsuro Yamaguchi, Kenshi Kosaka, Shigehisa Kajikawa |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Procalcitonin Sepsis 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Thoracic Oncology Internal medicine parasitic diseases medicine Humans Lung cancer Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Cancer General Medicine Middle Aged Prognosis medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Biomarker (medicine) Female Non small cell business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Tumori Journal. 107:385-391 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/0300891620966647 |
| Popis: | Introduction: Increased serum procalcitonin (PCT), a well-known biomarker for sepsis, has been reported in several cancer types. We aimed to investigate the prognostic impact of PCT in non-small cell lung cancer (NSCLC). Methods: Medical records of 51 consecutive patients with NSCLC (Aichi Medical University Hospital) admitted between July 2017 and July 2018 were retrospectively reviewed. The patients were divided into PCT-low (PCT < 0.1 ng/mL) and PCT-high (PCT ⩾ 0.1 ng/mL) groups, and their clinical characteristics and survival were compared. Results: In contrast to the PCT-low group (n = 24), the PCT-high group (n = 27) showed significantly worse Performance Status (PS) and overall survival (OS) (PS 0–2/3–4, 16/8 versus 12/15, p = 0.034; median OS, not reached versus 127 days, p < 0.001), irrespective of the presence of infection ( p = 0.785). Multivariate analysis showed that the disease stage (IV versus I–III) and high PCT level (⩾0.1 versus Conclusion: The results suggest that serum PCT in NSCLC was elevated regardless of the presence of infection. Higher PCT levels are associated with poor PS and shorter OS in NSCLC. |
| Databáze: | OpenAIRE |
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