Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis
| Autor: | Youkyung S. Roh, Isabelle D. Brown, Sylvie Gabriel, Rajeev Chavda, Pegah R. Bakhshi, Justin Choi, Kyle A. Williams, Shawn G. Kwatra, Nishadh Sutaria |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
030226 pharmacology & pharmacy Pharmacological treatment 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Pharmacology (medical) In patient General Pharmacology Toxicology and Pharmaceutics Intensive care medicine business.industry Pruritus Inflammatory skin disease Treatment options General Medicine medicine.disease Molecular biomarkers Pathophysiology Review article 030220 oncology & carcinogenesis Chronic Disease Quality of Life Prurigo business Biomarkers Prurigo nodularis |
| Zdroj: | Expert Review of Clinical Pharmacology. 14:67-77 |
| ISSN: | 1751-2441 1751-2433 |
| Popis: | Introduction: Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by intensely pruritic, hyperkeratotic nodules distributed on the trunk and extensor surfaces of the extremities. PN has a profoundly negative impact on sleep and quality of life in patients with PN. There are currently no U.S. Food and Drug Administration-approved agents and patients are often recalcitrant to current therapies, highlighting the importance of further research into this severely debilitating condition. Areas covered: A PubMed search was conducted to find available literature on the pathophysiology and clinical management of PN. In this review article, we discuss the current understanding of the pathophysiology, recommended diagnostic approach, and treatment options available for PN. Expert opinion/commentary: PN is an extremely difficult condition to treat, because there is a lack of effective therapies available due to our limited understanding of its pathophysiology. Currently, available treatment options are often multimodal due to the intersection of neuroimmune etiologic factors in the pathogenesis of PN. Fortunately, as our knowledge of PN expands, novel treatments targeting specific molecular biomarkers of PN are emerging, providing hope to this long-suffering patient population. |
| Databáze: | OpenAIRE |
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