Qualitative changes in symptomatology as an effect of treatment with escitalopram in generalized anxiety disorder and major depressive disorder
Autor: | Yves Lecrubier, Ornah T. Dolberg, Emmanuelle Weiller, Henning F. Andersen |
---|---|
Rok vydání: | 2007 |
Předmět: |
medicine.medical_specialty
Generalized anxiety disorder Databases Factual Hamilton Anxiety Rating Scale Citalopram behavioral disciplines and activities Rating scale mental disorders medicine Humans Escitalopram Pharmacology (medical) Psychiatry Biological Psychiatry Depression (differential diagnoses) Psychiatric Status Rating Scales Depressive Disorder Major General Medicine medicine.disease Anxiety Disorders Psychiatry and Mental health Treatment Outcome Montgomery–Åsberg Depression Rating Scale Antidepressive Agents Second-Generation Major depressive disorder Anxiety medicine.symptom Psychology Selective Serotonin Reuptake Inhibitors medicine.drug Clinical psychology |
Zdroj: | European Archives of Psychiatry and Clinical Neuroscience. 258:171-178 |
ISSN: | 1433-8491 0940-1334 |
Popis: | The purpose of this article is to examine the similarities and differences between patients with Major Depressive Disorder (MDD) versus Generalized Anxiety Disorder (GAD) versus MDD with anxiety symptoms. Data were analysed from all randomized double-blind clinical studies with escitalopram that measured symptoms using either Hamilton Anxiety Scale (HAMA) or Montgomery-Asberg Depression Rating Scale (MADRS). The contribution of each item of a scale to the total score was calculated before and after treatment, in remitters. Most single items of the HAMA contribute nearly equally in patients with GAD. In patients with MDD, four symptoms (i.e. anxious mood, tension, insomnia and concentration) contribute to most to the HAMA total score. In patients with GAD, three symptoms (tension, sleep and concentration) contribute two-thirds of the MADRS total score. In contrast, most MADRS items contribute equally to the total score in patients with MDD. After treatment to remission, the profile of residual symptoms MDD or GAD was similar to the symptom profile before treatment. Anxiety symptoms are very common in patients with MDD or GAD, and the symptomatic pattern is similar. In both disorders, the symptomatic pattern of residual symptoms is similar to the pattern of symptoms before treatment. |
Databáze: | OpenAIRE |
Externí odkaz: |