Perfusion CT Changes in Liver Metastases from Pancreatic Neuroendocrine Tumors During Everolimus Treatment
| Autor: | Valentina Ciaravino, Luca Landoni, Paola Vallerio, Sara Cingarlini, Aldo Scarpa, Stefano Crosara, Elisabetta Grego, Silvia Ortolani, Riccardo De Robertis, Mirko D'Onofrio, Claudio Bassi, Andrea Ruzzenente, Giampaolo Tortora |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Cancer Research Contrast Media Antineoplastic Agents Blood volume Neuroendocrine tumors pancreatic neuroendocrine tumor perfusion 030218 nuclear medicine & medical imaging predictive biomarkers Lesion 03 medical and health sciences Perfusion CT everolimus 0302 clinical medicine Biomarkers Tumor medicine Humans Prospective Studies Neoplasm Metastasis Stage (cooking) Aged Everolimus business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Intensity (physics) Pancreatic Neoplasms Neuroendocrine Tumors Treatment Outcome Liver Oncology 030220 oncology & carcinogenesis Time to peak Female medicine.symptom Tomography X-Ray Computed Nuclear medicine business Perfusion medicine.drug |
| Zdroj: | Anticancer Research. 37:1305-1312 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.11448 |
| Popis: | Aim To evaluate modifications of perfusional parameters assessed by perfusion computed tomography (P-CT) of liver metastases (LM) from pancreatic neuroendocrine tumors (PanNETs) during everolimus treatment. Patients and methods All patients with LMs from G1-2 PanNETs undergoing everolimus treatment between January 2013 and January 2015 were prospectively evaluated with P-CT at baseline, and after 2 and 4 months of therapy. Size, perfusion, blood volume (BV), peak enhancement intensity (PEI) and time to peak for each lesion were calculated. Results A total of 33 LMs in nine patients with G1-2 PanNETs were prospectively evaluated: 23/33 (69.7%) were responders, 10/33 (30.3%) were non-responders. Among perfusional parameters, only numerical peak enhancement intensity values significantly differed between the two groups at baseline (p=0.043). BV increase was the most significant perfusional modification identifying responding lesions, even at an early stage of treatment, with a high positive predictive value (89.47%). Conclusion P-CT seems to be useful for prediction of response to everolimus of LMs from PanNETs. |
| Databáze: | OpenAIRE |
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