Di (2-ethylhexyl) phthalate (DEHP) alters proliferation and uterine gland numbers in the uteri of adult exposed mice
| Autor: | Jodi A. Flaws, Kadeem A. Richardson, Maung Sun Myint, Romana A. Nowak, Yvette J. Johnson-Walker, Patrick R. Hannon |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system Uterus Endocrine Disruptors 010501 environmental sciences Biology Toxicology 01 natural sciences Andrology Mice 03 medical and health sciences chemistry.chemical_compound Plasticizers Diethylhexyl Phthalate medicine Animals Progesterone Cell Proliferation 0105 earth and related environmental sciences Reproductive function Estradiol Adult female Phthalate Epithelial Cells Epithelium Vasodilation 030104 developmental biology medicine.anatomical_structure chemistry Blood Vessels Female Stromal Cells Uterine gland Homeostasis Blood vessel |
| Zdroj: | Reproductive Toxicology. 77:70-79 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2018.01.006 |
| Popis: | Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine-disrupting chemical that has been shown to impair normal reproductive function in males and females. This study investigated whether adult exposure to environmental and occupational doses of DEHP alters homeostasis of uterine proliferation, morphology, and number of uterine glands. Adult female CD1 mice were orally dosed with DEHP (0, 20 μg/kg/day, 200 μg/kg/day, 20 mg/kg/day or 200 mg/kg/day) for 30 days. Results indicated that DEHP at 200 μg/kg/day caused a reduction in epithelial cell proliferation in the uterus (p .05). We also observed an increase (p .05) in the number of uterine glands in mice dosed with 200 mg/kg/day DEHP. Results showed that DEHP caused an increase (p .05) in dilated blood vessels in the endometrium at 200 μg/kg/day, 20 mg/kg/day and 200 mg/kg/day. DEHP also increased proliferation of endometrial stromal cells at 200 μg/kg/day DEHP (p .0010), 20 mg/kg/day DEHP (p .0001) and 200 mg/kg/day DEHP (p .0186). Results suggest that, exposure to specific doses of DEHP for 30 days can have adverse effects on reproductive function. |
| Databáze: | OpenAIRE |
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