The Role of Donor Bone Marrow Infusions in Withdrawal of Immunosuppression in Adult Liver Allotransplantation
| Autor: | Arie Regev, Violet Esquenazi, Juan Madariaga, Panagiotis Tryphonopoulos, Philip Ruiz, Jang Moon, Amr S. Khaled, David Levi, Caio Nery, Camillo Ricordi, Pablo A. Bejarano, Gennaro Selvaggi, Rolando Garcia-Morales, Seigo Nishida, Gary Kleiner, Joshua Miller, Debbie Weppler, Andreas G. Tzakis, Tomoaki Kato |
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| Rok vydání: | 2005 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Time Factors medicine.medical_treatment Liver transplantation Graft function Donor bone marrow medicine Humans Immunology and Allergy Pharmacology (medical) Bone Marrow Transplantation Immunosuppression Therapy Transplantation business.industry Significant difference Immunosuppression Tissue Donors Liver Transplantation Surgery Female Adult liver business Allotransplantation |
| Zdroj: | American Journal of Transplantation. 5:608-613 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/j.1600-6143.2004.00743.x |
| Popis: | We investigated the role of donor bone marrow cell (DBMC) infusions in immunosuppression withdrawal in adult liver transplantation. Patients enrolled were at least 3 years post-transplantation, with stable graft function. Forty-five (study group: G1) received DBMC, and 59 (control group: G2) did not. Immunosuppression was reduced by one third upon enrollment, by another third the second year of the study and was completely withdrawn the third year. Patient and graft survival were similar between the two groups. Although rejection episodes were significantly less in G1 the first 2 years of the study (35% vs. 57%, p = 0.016), there was no significant difference overall (74% vs. 81%, p = 0.14). Until February 2004, 20 patients, 10 in each group, were immunosuppression free for 1–3 years. Approximately 20% of long-term survivors of liver transplantation can successfully discontinue their immunosuppression. DBMC infusions, do not increase this likelihood. |
| Databáze: | OpenAIRE |
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