The Chemistry of Griseofulvin
| Autor: | Asger B. Petersen, Mads Hartvig Clausen, Mads Holger Rønnest, Thomas Ostenfeld Larsen |
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| Rok vydání: | 2014 |
| Předmět: |
MICROBIAL TRANSFORMATION
Filamentous fungi Research efforts Antifungal Agents Chemical structure CELL-FREE SYSTEM Anti fungal Microbial transformation Griseofulvin Cell-free system chemistry.chemical_compound SDG 3 - Good Health and Well-being Organic chemistry Synthetic routes NUCLEAR-MAGNETIC-RESONANCE B CARBON ANALOG CANCER-CELLS Mode of action CHEMISTRY Natural products Molecular Structure Chemistry TOTALSYNTHESE VON GRISEOFULVIN CHEMICAL STRUCTURE Fungi Stereoisomerism IN-VITRO Anti-fungal General Chemistry Ketones Polyketides STREPTOMYCES-CINEREOCROCATUS DL-GRISEOFULVIN |
| Zdroj: | Petersen, A B, Rønnest, M H, Larsen, T O & Clausen, M H 2014, ' The Chemistry of Griseofulvin ', Chemical Reviews, vol. 114, no. 24, pp. 12088-12107 . https://doi.org/10.1021/cr400368e |
| ISSN: | 1520-6890 0009-2665 |
| DOI: | 10.1021/cr400368e |
| Popis: | Specific synthetic routes are presented in schemes to illustrate the chemistry, and the analogs are presented in a table format to give an accessible overview of the structures. Several patents have been published regarding the properties of griseofulvin and its derivatives including synthesis, formulation, and their medicinal and agricultural applications. The antifungal mode-of-action of griseofulvin has been the subject of considerable research efforts and some debate over the years, a discussion that is still ongoing. Griseofulvin was one of the first antifungal natural products found in filamentous fungi. During the years, this polyketide has been found to be produced by several Ascomycetes including both closely and distantly related species. |
| Databáze: | OpenAIRE |
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