Hair and stress: A pilot study of hair and cytokine balance alteration in healthy young women under major exam stress

Autor: Herbert Fliege, Yvonne Müller, Thomas Schmidt-Rose, Heiner Max, Dorothea Schweiger, A. Reißhauer, Matthias Rose, Johannes Kruse, Wenke Snaga, Eva M.J. Peters
Rok vydání: 2016
Předmět:
0301 basic medicine
Pathology
Self-Assessment
Students
Medical
Time Factors
Hair Growth
Hydrocortisone
Physiology
medicine.medical_treatment
lcsh:Medicine
Social Sciences
600 Technik
Medizin
angewandte Wissenschaften::610 Medizin und Gesundheit
Biochemistry
0302 clinical medicine
Hair cycle
Surveys and Questionnaires
Immune Physiology
Medicine and Health Sciences
Psychology
Chronic stress
Lipid Hormones
lcsh:Science
Th1-Th2 Balance
Innate Immune System
Multidisciplinary
Telogen Phase
Middle Aged
Body Fluids
Distress
Cytokine
Blood
Cytokines
Female
Anatomy
Integumentary System
Research Article
Adult
medicine.medical_specialty
Adolescent
education
Primary Cell Culture
Immunology
Psychological Stress
03 medical and health sciences
Mental Health and Psychiatry
medicine
Humans
Catagen Phase
Balance (ability)
Steroid Hormones
business.industry
lcsh:R
Case-control study
Biology and Life Sciences
Molecular Development
medicine.disease
Hormones
030104 developmental biology
Hair loss
Case-Control Studies
Immune System
Leukocytes
Mononuclear
lcsh:Q
Educational Measurement
business
Physiological Processes
030217 neurology & neurosurgery
Stress
Psychological
Hair
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0175904 (2017)
ISSN: 1932-6203
Popis: Mouse models show that experimental stress mimicking prolonged life-stress exposure enhances neurogenic inflammation, induces adaptive immunity cytokine- imbalance characterized by a shift to Type 1 T-helper cell cytokines and increases apoptosis of epithelial cells. This affects hair growth in otherwise healthy animals. In this study, we investigate whether a prolonged naturalistic life-stress exposure affects cytokine balance and hair parameters in healthy humans. 33 (18 exam, 15 comparison) female medical students with comparable sociobiological status were analyzed during a stressful final examination period, at three points in time (T) 12 weeks apart. T1 was before start of the learning period, T2 between the three-day written exam and an oral examination, and T3 after a 12 week rest and recovery from the stress of the examination period. Assessments included: self-reported distress and coping strategies (Perceived Stress Questionnaire [PSQ], Trier Inventory for the Assessment of Chronic Stress [TICS]), COPE), cytokines in supernatants of stimulated peripheral blood mononucleocytes (PBMCs), and trichogram (hair cycle and pigmentation analysis). Comparison between students participating in the final medical exam at T2 and non-exam students, revealed significantly higher stress perception in exam students. Time-wise comparison revealed that stress level, TH1/TH2 cytokine balance and hair parameters changed significantly from T1 to T2 in the exam group, but not the control. However, no group differences were found for cytokine balance or hair parameters at T2. The study concludes that in humans, naturalistic stress, as perceived during participation in a major medical exam, has the potential to shift the immune response to TH1 and transiently hamper hair growth, but these changes stay within a physiological range. Findings are instructive for patients suffering from hair loss in times of high stress. Replication in larger and more diverse sample populations is required, to assess suitability of trichogram analysis as biological outcome for stress studies.
Databáze: OpenAIRE
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