Ozone depletes tocopherols and tocotrienols topically applied to murine skin
| Autor: | Maurizio Podda, Lester Packer, Maret G. Traber, Kenneth Tsang, Carroll E. Cross, Jens J. Thiele |
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| Rok vydání: | 1997 |
| Předmět: |
Vitamin
Antioxidant Hairless mice Administration Topical medicine.medical_treatment Biophysics Palm Oil Pharmacology Biochemistry Antioxidants Lipid peroxidation Mice chemistry.chemical_compound Oxidants Photochemical Ozone Structural Biology Malondialdehyde PEG ratio Genetics medicine Animals Plant Oils Vitamin E Butylated hydroxytoluene Cutaneous lipid Molecular Biology Skin Mice Hairless integumentary system Cell Biology Lipid Metabolism Hairless chemistry Female Lipid Peroxidation Epidermis |
| Zdroj: | FEBS Letters. 401:167-170 |
| ISSN: | 0014-5793 |
| Popis: | To evaluate ozone damage to hairless mouse skin, two parameters of oxidative damage, vitamin E depletion and malondialdehyde (MDA) production, were measured in vitamin E-enriched and in control skin from mice exposed to ozone (10 ppm). A 5% vitamin E solution (tocotrienol-rich fraction, TRF) in polyethylene glycol (PEG) was applied to 2 sites on the back of hairless mice, PEG to 2 sites. After 2 h, the sites were washed, one of each pair of sites covered and the mice exposed ozone for 2 h. Ozone exposure (compared with covered sites) increased epidermal MDA in PEG-treated sites, while vitamin E was unchanged. In contrast, ozone exposure significantly depleted vitamin E in TRF-treated sites, while significant MDA accumulation was prevented. This is the first demonstration that ozone exposure causes damage to cutaneous lipids, an effect which can be attenuated by vitamin E application. |
| Databáze: | OpenAIRE |
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