An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells (MSC) Committee perspectives on International Standards Organization/Technical Committee 276 Biobanking Standards for bone marrow-MSCs and umbilical cord tissue-derived MSCs for research purposes
Autor: | Sowmya Viswanathan, Katarina Le Blanc, Rachele Ciccocioppo, Georges Dagher, Anthony J. Filiano, Jacques Galipeau, Mauro Krampera, Lena Krieger, Manoj M. Lalu, Jan Nolta, Viviana Marcela Rodriguez Pardo, Yufang Shi, Karin Tarte, Daniel J. Weiss, Ivan Martin |
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Přispěvatelé: | University Health Network, University of Toronto, Karolinska Institutet [Stockholm], Università degli studi di Verona = University of Verona (UNIVR), Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Duke University Medical Center, University of Wisconsin-Madison, Deutsches Institut für Normung (DIN), Ottawa Hospital Research Institute [Ottawa] (OHRI), University of California [Davis] (UC Davis), University of California (UC), Pontificia Universidad Javeriana (PUJ), Soochow University, Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer (MOBIDIC), Université de Rennes (UR)-Etablissement français du sang [Rennes] (EFS Bretagne)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Vermont [Burlington], University Children’s Hospital Basel = Hôpital pédiatrique universitaire des deux Bâle [Bâle, Suisse] (UKBB) |
Jazyk: | angličtina |
Rok vydání: | 2023 |
Předmět: | |
Zdroj: | Cytotherapy Cytotherapy, 2023, ⟨10.1016/j.jcyt.2023.04.005⟩ |
ISSN: | 1465-3249 |
Popis: | International audience; The rapidly growing field of mesenchymal stromal cell (MSC) basic and translational research requires standardization of terminology and functional characterization. The International Standards Organization’s (ISO) Technical Committee (TC) on Biotechnology, working with extensive input from the International Society for Cells and Gene Therapy (ISCT), has recently published ISO standardization documents that are focused on biobanking of MSCs from two tissue sources, Wharton’s Jelly, MSC(WJ) and Bone Marrow, MSC(M)), for research and development purposes and development. This manuscript explains the path towards the consensus on the following two documents: the Technical Standard ISO/TS 22859 for MSC(WJ) and the full ISO Standard 24651 for MSC(M) biobanking. The ISO standardization documents are aligned with ISCT’s MSC committee position and recommendations on nomenclature because there was active input and incorporation of ISCT MSC committee recommendations in the development of these standards. The ISO standardization documents contain both requirements and recommendations for functional characterization of MSC(WJ) and MSC(M) using a matrix of assays. Importantly, the ISO standardization documents have a carefully defined scope and are meant for research use of culture expanded MSC(WJ) and MSC(M). The ISO standardization documents can be updated in a revision process and will be systematically reviewed after 3-5 years as scientific insights grow. They represent international consensus on MSC identity, definition, and characterization; are rigorous in detailing multivariate characterization of MSCs and represent an evolving-but-important first step in standardization of MSC biobanking and characterization for research use and development. |
Databáze: | OpenAIRE |
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