Cytochrome P450S and Alcoholic Liver Disease
| Autor: | Yongke Lu, Arthur I. Cederbaum |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
congenital hereditary and neonatal diseases and abnormalities Alcoholic liver disease medicine.medical_specialty endocrine system diseases Alcohol Article Microsomal ethanol oxidizing system 03 medical and health sciences chemistry.chemical_compound Cytochrome P-450 Enzyme System Internal medicine Drug Discovery medicine Animals Humans Ethanol metabolism CYP2A6 Liver Diseases Alcoholic Alcohol dehydrogenase Pharmacology biology nutritional and metabolic diseases Cytochrome P450 CYP2E1 medicine.disease Alcohol Oxidoreductases 030104 developmental biology Endocrinology chemistry biology.protein |
| Zdroj: | Current Pharmaceutical Design. 24:1502-1517 |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/1381612824666180410091511 |
| Popis: | Alcohol consumption causes liver diseases, designated as Alcoholic Liver Disease (ALD). Because alcohol is detoxified by alcohol dehydrogenase (ADH), a major ethanol metabolism system, the development of ALD was initially believed to be due to malnutrition caused by alcohol metabolism in liver. The discovery of the microsomal ethanol oxidizing system (MEOS) changed this dogma. Cytochrome P450 enzymes (CYP) constitute the major components of MEOS. Cytochrome P450 2E1 (CYP2E1) in MEOS is one of the major ROS generators in liver and is considered to be contributive to ALD. Our labs have been studying the relationship between CYP2E1 and ALD for many years. Recently, we found that human CYP2A6 and its mouse analog CYP2A5 are also induced by alcohol. In mice, the alcohol induction of CYP2A5 is CYP2E1-dependent. Unlike CYP2E1, CYP2A5 protects against the development of ALD. The relationship of CYP2E1, CYP2A5, and ALD is a major focus of this review. |
| Databáze: | OpenAIRE |
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