Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans
| Autor: | Valerie Reinke, Min Jiang, Monika Kiraly, Jubin Ryu, Stuart K. Kim, Kyle Duke |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Aging Sex Differentiation Pair-rule gene Disorders of Sex Development Biology Genome Gene density Cyclins Proto-Oncogene Proteins Gene expression Gene cluster Animals Genes Retinoblastoma Caenorhabditis elegans Gene Genes Helminth Oligonucleotide Array Sequence Analysis Genetics Sex Characteristics Multidisciplinary Gene Expression Profiling Gene Expression Regulation Developmental Genomics Zebrafish Proteins Biological Sciences biology.organism_classification Wnt Proteins Female DNA microarray Signal Transduction Transcription Factors |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 98(1) |
| ISSN: | 0027-8424 |
| Popis: | We have constructed DNA microarrays containing 17,871 genes, representing about 94% of the 18,967 genes currently annotated in the Caenorhabditis elegans genome. These DNA microarrays can be used as a tool to define a nearly complete molecular profile of gene expression levels associated with different developmental stages, growth conditions, or worm strains. Here, we used these full-genome DNA microarrays to show the relative levels of gene expression for nearly every gene during development, from eggs through adulthood. These expression data can help reveal when a gene may act during development. We also compared gene expression in males to that of hermaphrodites and found a total of 2,171 sex-regulated genes ( P < 0.05). The sex-regulated genes provide a global view of the differences between the sexes at a molecular level and identify many genes likely to be involved in sex-specific differentiation and behavior. |
| Databáze: | OpenAIRE |
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