Results of Preoperative Lymphoscintigraphy for Breast Cancer Are Predictive of Identification of Axillary Sentinel Lymph Nodes
| Autor: | François Guillemin, Philippe Rauch, Frédéric Marchal, Agnès Leroux, Pierre Olivier, Jean Luc Verhaeghe, Olivier Morel, Jean Claude Mayer |
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| Přispěvatelé: | Centre Alexis Vautrin (CAV), Service de Médecine Nucléaire [Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Axillary lymph nodes medicine.medical_treatment Sentinel lymph node Breast Neoplasms Mastectomy Segmental Scintigraphy 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Biopsy medicine Carcinoma Humans Prospective Studies Radionuclide Imaging Prospective cohort study Aged Aged 80 and over medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Carcinoma Ductal Breast Middle Aged medicine.disease 3. Good health Surgery [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biophysics Carcinoma Lobular medicine.anatomical_structure 030220 oncology & carcinogenesis Multivariate Analysis Lymph Node Excision Female Lymph Nodes Radiology business Mastectomy |
| Zdroj: | World Journal of Surgery World Journal of Surgery, Springer Verlag, 2006, 30, pp.55-62. ⟨10.1007/s00268-005-0145-3⟩ |
| ISSN: | 1432-2323 0364-2313 |
| DOI: | 10.1007/s00268-005-0145-3 |
| Popis: | International audience; The aim of this study was to identify the variables associated with successful peroperative sentinel lymph node (SLN) localization. We studied 201 patients with T1, T2, N0 invasive breast cancer who underwent a SLN procedure from 1999 to 2003. Of these 201 patients, 55 underwent peritumoral and 146 underwent periareolar radioisotope injection before the blue dye injection. All patients were operated on by breast conservative surgery and axillary dissection after SLN biopsy. Age, weight, menopausal status, previous biopsy, localization of the tumor, results of lymphoscintigraphy, site of radiotracer injection, tumor size, tumor grade, experience of surgeons, and the number of invaded axillary nodes were analyzed to determine whether they had any significant correlation with successful identification of SLN. Variables found to have a statistically significant influence on the SLN identification rate and on preoperative lymphoscintigraphy identification were introduced into a univariate and multivariate logistic regression model. In multivariate analysis, successful lymphoscintigraphy (P < 0.0001) and the absence of metastatic axillary nodes (P < 0.005) were associated with successful identification of SLNs. The peritumoral injection of radiotracer (P < 0.001), patient age > 60 years (P < 0.003), and localization of the tumor in the upper outer quadrant (P < 0.004) were associated with failure of lymphoscintigraphic visualization of SLN. The technique of SLN detection thus appears to be better for patients with low risk of invaded axillary lymph nodes. |
| Databáze: | OpenAIRE |
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