Genetic variants in the microRNA machinery gene (Dicer) have a prognostic value in the management of endometrial cancer
| Autor: | Malik Ejder Yildirim, Gokhan Bagci, Binnur Bagci, Ali Yanık, Muhammed Oz, Özlem Bozoklu Akkar, Caglar Yildiz, Ismail Sari, Savas Karakus, Ali Cetin |
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| Přispěvatelé: | [Oz, Muhammed -- Karakus, Savas -- Yildiz, Caglar -- Akkar, Ozlem -- Cetin, Ali -- Yanik, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Yildirim, Malik -- Bagci, Gokhan] Cumhuriyet Univ, Sch Med, Dept Med Genet, Sivas, Turkey -- [Sari, Ismail] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth Sci, Dept Nutr & Dietet, TR-58140 Sivas, Turkey, Cetin, Ali -- 0000-0002-5767-7894, Sari, Ismail -- 0000-0003-3732-2102 |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Ribonuclease III medicine.medical_specialty Genotype Lymphovascular invasion Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide lcsh:RC254-282 DEAD-box RNA Helicases 03 medical and health sciences Gene Frequency single nucleotide polymorphism Internal medicine medicine SNP Humans Radiology Nuclear Medicine and imaging Genetic Predisposition to Disease Allele Allele frequency Alleles microRNA Endometrial cancer General Medicine Middle Aged medicine.disease Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Endometrial Neoplasms MicroRNAs 030104 developmental biology Case-Control Studies endometrial cancer biology.protein Female Neoplasm Recurrence Local Dicer |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 14, Iss 6, Pp 1279-1284 (2018) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | WOS: 000452548200021 PubMed ID: 30488844 Aim: Although several associations were found between Dicer rs3742330 single nucleotide polymorphism (SNP) and development and prognosis of some epithelial cancers, relationship between the SNP rs3742330 and endometrial cancer (EC) has not yet been studied. We aimed to investigate the prognostic role of rs3742330 SNP of Dicer gene in EC patients. Subjects and Methods: A total of 80 EC patients and 80 control subjects included in the study. Real-time polymerase chain reaction and the allele discrimination technique was used for genotyping of rs3742330 SNP. Results: There was no significant difference between EC patients and control subjects with regard to the genotype and allele frequencies for Dicer rs3742330 SNP (P > 0.05). Despite Dicer rs3742330 SNP had no prognostic value in terms of stage, grade, lymphovascular invasion, myometrial invasion, tumor size, and histopathology; malignant peritoneal cytology has been detected higher in the patients bearing AA genotype compare with AG genotype (P = 0.023). Higher recurrence rate and shorter time to recurrence were found in patients bearing AG and GG genotype compare with AA genotype (P = 0.009). Conclusion: Dicer rs3742330 AG and GG genotypes may have the potential to be used as a predictor of poor prognosis in the management of EC case. Scientific Research Project Fund of Cumhuriyet University [T-620] This work is supported by the Scientific Research Project Fund of Cumhuriyet University under the project number "T-620." |
| Databáze: | OpenAIRE |
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