Exercise capacity in patients with cystic fibrosis vs. non-cystic fibrosis bronchiectasis

Autor: Gur Mainzer, Lea Bentur, Ronen Bar-Yoseph, Fahed Hakim, Yael Subar, Michal Gur, Merav Zucker-Toledano, Dan M. Cooper, George Shalloufeh, Galit Livnat, Zeev Schnapp, Anat Ilivitzki
Přispěvatelé: Solevåg, Anne Lee
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Cystic Fibrosis
Pulmonology
Etiology
Physiology
030204 cardiovascular system & hematology
Cardiovascular
Pathology and Laboratory Medicine
Cystic fibrosis
Diagnostic Radiology
Congenital
0302 clinical medicine
Medicine and Health Sciences
Medicine
Respiratory Analysis
Public and Occupational Health
Prospective Studies
Prospective cohort study
Lung
Tomography
Multidisciplinary
Exercise Tolerance
medicine.diagnostic_test
Respiration
Radiology and Imaging
VO2 max
Sports Science
Bronchiectasis
Chemistry
Bioassays and Physiological Analysis
Genetic Diseases
Breathing
Physical Sciences
Cardiology
Female
Research Article
Chemical Elements
Spirometry
Adult
Pediatric Research Initiative
medicine.medical_specialty
Adolescent
General Science & Technology
Imaging Techniques
Science
Oxygen pulse
Neuroimaging
Research and Analysis Methods
03 medical and health sciences
FEV1/FVC ratio
Young Adult
Rare Diseases
Oxygen Consumption
Autosomal Recessive Diseases
Clinical Research
Diagnostic Medicine
Internal medicine
MD Multidisciplinary
Humans
Exercise physiology
Sports and Exercise Medicine
Exercise
Retrospective Studies
Clinical Genetics
business.industry
Biology and Life Sciences
Physical Activity
medicine.disease
Fibrosis
Computed Axial Tomography
Oxygen
Cross-Sectional Studies
030228 respiratory system
Physical Fitness
Exercise Test
Quality of Life
business
Physiological Processes
Developmental Biology
Neuroscience
Zdroj: PLoS ONE, Vol 14, Iss 6, p e0217491 (2019)
PLoS ONE
PloS one, vol 14, iss 6
Bar-Yoseph, Ronen; Ilivitzki, Anat; Cooper, Dan M; Gur, Michal; Mainzer, Gur; Hakim, Fahed; et al.(2019). Exercise capacity in patients with cystic fibrosis vs. non-cystic fibrosis bronchiectasis.. PloS one, 14(6), e0217491. doi: 10.1371/journal.pone.0217491. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3fs5s8j0
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0217491.
Popis: Author(s): Bar-Yoseph, Ronen; Ilivitzki, Anat; Cooper, Dan M; Gur, Michal; Mainzer, Gur; Hakim, Fahed; Livnat, Galit; Schnapp, Zeev; Shalloufeh, George; Zucker-Toledano, Merav; Subar, Yael; Bentur, Lea | Abstract: BackgroundBronchiectasis is associated with morbidity, low exercise capacity and poor quality of life. There is a paucity of data on exercise capacity using cardiopulmonary exercise test (CPET) in non-cystic fibrosis (CF) bronchiectasis. Our aim was to compare exercise capacity using CPET in CF and non-CF bronchiectasis patients.MethodsCross-sectional retrospective/prospective controlled study assessing CPET using cycle ergometer. Exercise parameters and computed tomography (CT) findings were compared. Results: Hundred two patients with bronchiectasis and 88 controls were evaluated; 49 CF (age 19.7 ± 9.7 y/o, FEV1%predicted 70.9 ± 20.5%) and 53 non-CF (18.6 ± 10.6 y/o, FEV1%predicted 68.7 ± 21.5%). Peak oxygen uptake (peak [Formula: see text]) was similar and relatively preserved in both groups (CF 1915.5±702.0; non-CF 1740±568; control 2111.0±748.3 mL/min). Breathing limitation was found in the two groups vs. control; low breathing reserve (49% in CF; 43% non-CF; 5% control) and increased [Formula: see text] (CF 31.4±4.1, non-CF 31.7±4.1 and control 27.2 ± 2.8). Oxygen pulse was lower in the non-CF; whereas a linear relationship between peak [Formula: see text] vs. FEV1 and vs. FVC was found only for CF. CT score correlated with [Formula: see text] and negatively correlated with [Formula: see text] and post exercise oxygen saturation (SpO2).ConclusionsCPET parameters may differ between CF and non-CF bronchiectasis. However, normal exercise capacity may be found unrelated to the etiology of the bronchiectasis. Anatomical changes in CT are associated with functional finding of increased [Formula: see text] and decreased SpO2. Larger longitudinal studies including cardiac assessment are needed to better study exercise capacity in different etiologies of non-CF bronchiectasis.Trial registrationClinicalTrials.gov, registration number: NCT03147651.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje