Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Autor: Rong Zhu, Jiahuan Peng, Lixin Wang, Xiaochen Xie, Huanhuan Zuo
Rok vydání: 2019
Předmět:
Male
Cancer Research
Acute exacerbation of chronic obstructive pulmonary disease
Neutrophils
030204 cardiovascular system & hematology
Gastroenterology
Electrocardiography
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
Natriuretic Peptide
Brain
Medicine
Lymphocytes
RC254-282
Univariate analysis
Area under the curve
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
General Medicine
Predictive value of tests
Disease Progression
Molecular Medicine
Biomarker (medicine)
Female
Research Article
Blood Platelets
medicine.medical_specialty
Article Subject
Hypertension
Pulmonary
Pathology and Forensic Medicine
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Humans
Aged
Inflammation
QH573-671
Receiver operating characteristic
business.industry
Cell Biology
medicine.disease
Pulmonary hypertension
Carboxypeptidase B
Peptide Fragments
body regions
Blood pressure
ROC Curve
030228 respiratory system
Multivariate Analysis
Cytology
business
Biomarkers
Zdroj: Analytical Cellular Pathology (Amsterdam)
Analytical Cellular Pathology, Vol 2019 (2019)
ISSN: 2210-7185
2210-7177
Popis: Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD. According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups. The study group consisted of 101 patients complicated with PH, and the control group had 84 patients. The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (p<0.05). The blood biomarker levels were positively correlated with NT-proBNP levels, while they had no significant correlation with the estimated pulmonary arterial systolic pressure (PASP) other than PLR. NLR, PLR, and SII values were all associated with PH (p<0.05) in the univariate analysis, but not in the multivariate analysis. The AUC of NLR used for predicting PH was 0.701 and was higher than PLR and SII. Using 4.659 as the cut-off value of NLR, the sensitivity was 81.2%, and the specificity was 59.5%. In conclusion, these simple markers may be useful in the prediction of PH in patients with AECOPD.
Databáze: OpenAIRE
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