Prehospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk
| Autor: | Steven Y. Chang, Greg S. Martin, Nina T. Gentile, Daryl J. Kor, Nivedita Nagam, Remzi Iscimen, Mauricio Garcia, James M. Blum, Miriam M. Treggiari, Stephen Patrick Bender, Ivor S. Douglas, Ruxana T. Sadikot, Peter C. Hou, Adil Ahmed, David F. Gaieski, Michael Malinchoc, Shilpa Patel, Mary C. McCarthy, Sujatha Srinivasan, Srikanth Hosur, Paul N. Lanken, David A. Kaufman, Christy Dean, Melike Cengiz, Gyorgy Frendl, Chirag V. Shah, Annette M. Esper, Brian Hess, B. T. Thompson, Jonathan M Barry, Daniel Talmor, Jason D. Christie, Ognjen Gajic, Marie Carmelle Elie, Pauline K. Park, Atul Malhotra, J. Jason Hoth, Steven Deem, Adebola O. Adesanya, Amee Patrawalla, David C. Christiani, Michelle N. Gong, Ian Shempp, Murat Yilmaz, Barbara K. Yoza, Julie Harris, Kathryn M. Tchorz, Bekele Afessa, Brent Freeman, Rickey E. Carter, Victor Enoh, John R. Daniels, Robert C. Hyzy, Rodrigo Cartin-Ceba, Jonathan E. Sevransky, Lena M. Napolitano, Lioudmila V. Karnatovskaia, Emir Festic, Augustine Lee, Harry L. Anderson, Nuala J. Meyer, Krishnan Raghavendran, Ammar Karo, Ednan K. Bajwa, Mark E. Mikkelsen, Timothy R. Watkins, Ousama Dabbagh, Karen Stevenson, David Uddin, Augustine S. Lee |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty ARDS animal diseases Acute Lung Injury Amiodarone Lung injury Critical Care and Intensive Care Medicine Article Risk Factors Medicine Humans Prospective Studies Risk factor Prospective cohort study Intensive care medicine Diffuse alveolar damage Aged Respiratory Distress Syndrome business.industry Incidence (epidemiology) respiratory system Middle Aged medicine.disease Respiration Artificial respiratory tract diseases Clinical trial Emergency medicine Acute Disease Female business Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | Journal of critical care. 27(5) |
| ISSN: | 1557-8615 |
| Popis: | Amiodarone has been implicated as a risk factor for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) when used in the hospital. This study aims to estimate whether prehospital amiodarone also increases the risk of ALI/ARDS.Adult patients admitted to 22 centers with at least 1 risk factor for developing ALI were recruited. In a secondary analysis of this cohort, the prehospital use of amiodarone was documented on admission, and the patients followed for the primary outcome of ALI and secondary outcomes of ARDS, the need for invasive ventilation, and mortality. Dose/duration of amiodarone therapy was not available. Propensity matching was performed to account for imbalances in being assigned to amiodarone. The adjusted risk for ALI/ARDS was then estimated from a conditional logistic regression model of this propensity-matched set.Forty of 5584 patients were on amiodarone at the time of hospitalization; of those, 6 developed ALI, with 5 progressing to ARDS. In comparison, 371 patients not on amiodarone developed ALI, with 224 having ARDS. After propensity score matching, the prehospital use of amiodarone was not statistically associated with an increased risk for all ALI (odds ratio [OR], 1.8; 95% confidence interval [CI], 0.7-5.0; P = .25), invasive ventilation (OR, 1.9; 95% CI, 1.0-3.6; P = .059), or in-hospital mortality (OR, 1.2; 95% CI, 0.5-2.9; P = .75); but its use appeared to significantly increase the risk for ARDS (OR 3.8; 95% CI, 1.1-13.1; P = .036).Prehospital use of amiodarone may independently increase the risk for ARDS in patients who have at least 1 predisposing condition for ALI. |
| Databáze: | OpenAIRE |
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