The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis
| Autor: | Yajing Pan, Zhaoping Li, Irina Arnold, David Heber, Laura Sanavio, Tianyu Qin, Vivian Wang, Jieping Yang, Gail Thames, Chi-Hong Tseng, Ru-Po Lee, Joseph S. Yusin, Susanne M. Henning |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male peak nasal inspiratory flow antioxidant sulforaphane nasal corticosteroid Gastroenterology 0302 clinical medicine Adrenal Cortex Hormones Grass pollen Nasal mucus glutathione transferase Medicine T2 cytokines TX341-641 Broccoli sprout extract Lung broccoli sprout Rhinitis Nutrition and Dietetics Middle Aged Treatment Outcome Intranasal Peak Nasal Inspiratory Flow Combination Administration Corticosteroid Pollen Cytokines Drug Therapy Combination Female Nasal symptoms Adult medicine.medical_specialty medicine.drug_class Clinical Trials and Supportive Activities Allergic Rhinitis (Hay Fever) Brassica Placebo Poaceae Article 03 medical and health sciences Allergic Food Sciences Drug Therapy Double-Blind Method Clinical Research Internal medicine otorhinolaryngologic diseases Humans Administration Intranasal Aged Seasonal allergic rhinitis Nutrition. Foods and food supply business.industry Plant Extracts allergen extract Rhinitis Allergic Seasonal Nasal Sprays Allergens Nasal Mucosa 030104 developmental biology total nasal symptom score 030228 respiratory system Broccoli sprouts business Food Science |
| Zdroj: | Nutrients Nutrients, vol 13, iss 4 Volume 13 Issue 4 Nutrients, Vol 13, Iss 1337, p 1337 (2021) |
| ISSN: | 2072-6643 |
| Popis: | Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and randomized to one of four groups: group 1 (nasal steroid spray + BSE), group 2 (nasal steroid spray + placebo tablet), group 3 (saline nasal spray + BSE) and group 4 (saline nasal spray + placebo tablet). Peak Nasal Inspiratory Flow (PNIF), Total Nasal Symptoms Scores (TNSS) and nasal mucus cytokine levels were analyzed in samples collected before and after the 3-week intervention. Comparing before and after the intervention, PNIF improved significantly when comparing Groups 1 and 2, vs. placebo, at various time points (p ≤ 0.05 at 5, 15, 60 and 240 min) following nasal challenge, while TNSS was only statistically significant at 5 (p = 0.03), 15 (p = 0.057) and 30 (p = 0.05) minutes. There were no statistically significant differences in various cytokine markers before and after the intervention. Combining nasal corticosteroid with BSE led to the most significant improvement in objective measures. |
| Databáze: | OpenAIRE |
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