CaMKK2 Signaling in Metabolism and Skeletal Disease: a New Axis with Therapeutic Potential
| Autor: | Uma Sankar, Justin N. Williams |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Glycation End Products
Advanced 0301 basic medicine Aging Endocrinology Diabetes and Metabolism medicine.medical_treatment Calcium-Calmodulin-Dependent Protein Kinase Kinase 030209 endocrinology & metabolism Inflammation medicine.disease_cause Bioinformatics Article Energy homeostasis Bone remodeling 03 medical and health sciences 0302 clinical medicine Diabetes mellitus medicine Humans Obesity CAMKK2 Fracture Healing business.industry Insulin medicine.disease Bone Diseases Metabolic 030104 developmental biology Diabetes Mellitus Type 2 Adipogenesis medicine.symptom Energy Metabolism business Oxidative stress |
| Zdroj: | Current Osteoporosis Reports. 17:169-177 |
| ISSN: | 1544-2241 1544-1873 |
| DOI: | 10.1007/s11914-019-00518-w |
| Popis: | PURPOSE OF REVIEW: Age and metabolic disorders result in the accumulation of advanced glycation endproducts (AGEs), oxidative stress and inflammation, which cumulatively cause a decline in skeletal health. Bone becomes increasingly vulnerable to fractures and its regenerative capacity diminishes under such conditions. With a rapidly aging population in the United States and the global increase in diabetes, efficacious, multi-dimensional therapies that can treat or prevent skeletal diseases associated with metabolic dysfunction and inflammatory disorders are acutely needed. RECENT FINDINGS: Ca(2+)/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a key regulator of nutrient intake, glucose metabolism, insulin production and adipogenesis. Recent studies suggest a pivotal role for CaMKK2 in bone metabolism, fracture healing, and inflammation. SUMMARY: Aside from rekindling previous concepts of CaMKK2 as a potent regulator of whole-body energy homeostasis, this review emphasizes CaMKK2 as a potential therapeutic target to treat skeletal diseases that underlie metabolic conditions and inflammation. |
| Databáze: | OpenAIRE |
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