High Stroma T-Cell Infiltration is Associated with Better Survival in Stage pT1 Bladder Cancer

Autor: Sabine Hülsen, Fulvia Ferrazzi, Simone Bertz, Rainer Fietkau, Arndt Hartmann, Maximilian Burger, Johannes Breyer, Wolfgang Otto, Eleonora Lippolis, Carol-I Geppert, Markus Eckstein, Annette Ebner, Stefan Denzinger, Luitpold Distel
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
CD3 Complex
Lymphocyte
Cell
tumor-infiltrating lymphocytes (TILs)
CD3+ lymphocytes
CD8-Positive T-Lymphocytes
lcsh:Chemistry
0302 clinical medicine
Tumor Microenvironment
Medicine
lcsh:QH301-705.5
Spectroscopy
Aged
80 and over
biology
General Medicine
Middle Aged
Prognosis
Computer Science Applications
medicine.anatomical_structure
030220 oncology & carcinogenesis
pT1 bladder cancer
Female
Infiltration (medical)
Adult
CD3
immunoscore
survival
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Immune system
Lymphocytes
Tumor-Infiltrating
Stroma
Humans
ddc:610
Physical and Theoretical Chemistry
Molecular Biology
Aged
Neoplasm Staging
Bladder cancer
business.industry
CD8+ lymphocytes
Organic Chemistry
medicine.disease
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Urinary Bladder Neoplasms
Cancer research
biology.protein
progression
Neoplasm Recurrence
Local
business
CD8
Biomarkers
Zdroj: International Journal of Molecular Sciences
Volume 21
Issue 21
International Journal of Molecular Sciences, Vol 21, Iss 8407, p 8407 (2020)
ISSN: 1422-0067
Popis: Stage pT1 bladder cancer (BC) shows highly diverse outcomes. Predictive markers are required to stratify patients for personalized treatment. The present study aimed to validate immune response quantification as a prognostic marker. Patients with pT1 BC (n = 167) treated by transurethral resection of the bladder (TURB) were enrolled. Formaldehyde-fixed paraffin-embedded material was stained for CD3 and CD8. Corresponding T cells were counted in three regions with the highest immune response. Numbers of tertiary lymphoid structures (TLS) and lymphocyte aggregates (LA) were quantified. High CD3+ stroma T-cell infiltration was associated with improved survival (p = 0.045), especially in the G3 subgroup (p = 0.01). Cluster with higher immune response showed less recurrence (p = 0.034) and favorable overall survival (OS) (p = 0.019). In contrast, higher CD3+ and CD8+ tumor T-cell infiltration seemed to have a negative impact on prognosis. TLS and LA were more frequently observed in G3 tumors, indicating an increased anti-tumoral immune response. We proved the role of immune cell infiltration and showed that higher infiltration numbers of CD3+ (not CD8+) lymphocytes in the stroma are associated with favorable outcome. Immune cell quantification could be used as a marker to help stratify patients&rsquo
risk and therefore, to optimize patients&rsquo
management and follow-up examination as well as possible therapies.
Databáze: OpenAIRE
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