Higher fasting glucose is associated with poorer cognition among healthy young adults
| Autor: | Misty A.W. Hawkins, John Gunstad, Mary Beth Spitznagel, Dayana Calvo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Type 2 diabetes Body Mass Index Prediabetic State Young Adult 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine medicine Humans Obesity 030212 general & internal medicine Effects of sleep deprivation on cognitive performance Prediabetes Neuropsychological assessment Young adult Applied Psychology medicine.diagnostic_test Fasting medicine.disease Psychiatry and Mental health Endocrinology Female Cognition Disorders Psychology Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Health Psychology. 35:199-202 |
| ISSN: | 1930-7810 0278-6133 |
| Popis: | Objective Obesity is associated with cognitive deficits; however, the mechanisms are unclear, especially among otherwise healthy adults. Our objectives were to examine (a) whether obesity is linked to elevations in fasting glucose and (b) whether these elevations are associated with cognitive impairment among otherwise healthy young adults. Method Participants were 35 normal weight adults and 35 young adults with obesity who completed a task from the Automated Neuropsychological Assessment Metrics-4 (ANAM-4). Measured body mass index (BMI) and fasting blood glucose levels (mg/dL) were examined. Results Persons with obesity had higher fasting glucose levels than normal weight persons (p = .03). After applying Bonferroni correction for multiple tests, higher fasting glucose predicted less accurate performance on tests of inhibitory control: Go/No-Go Commission Errors (β = .33, p = .004). No effects were observed for sustained attention or working memory (ps ≥. 049). Persons with glucose levels in the prediabetes range had nearly twice as many errors as those with normal glucose, a large effect that was independent of BMI. Conclusions Young adults who were obese but otherwise healthy had higher fasting glucose levels compared with normal weight peers. Higher glucose levels were associated with poorer cognitive performance on tests of inhibitory control, especially among individuals with prediabetes levels. Thus, subclinical elevations in blood glucose may contribute to cognitive impairment and, ultimately, greater impulsivity-well in advance of the development of chronic disease states (e.g., insulin resistance or Type 2 diabetes) and independently of excess adiposity--though prospective studies are needed to determine directionality of this relationship. |
| Databáze: | OpenAIRE |
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