Analysis of formaldehyde in the headspace of urine from bladder and prostate cancer patients using selected ion flow tube mass spectrometry

Autor:	Tracey A. Holland, Waleed Al Singary, David Smith, James B. Elder, Patrik Španěl
Rok vydání:	1999
Předmět:	Male Chromatography Organic Chemistry Formaldehyde Healthy subjects Prostatic Neoplasms Urine medicine.disease Mass Spectrometry Analytical Chemistry Prostate cancer chemistry.chemical_compound chemistry Urinary Bladder Neoplasms medicine Humans Selected-ion flow-tube mass spectrometry Spectroscopy
Zdroj:	Scopus-Elsevier
ISSN:	0951-4198
Popis:	We have used selected ion flow tube mass spectrometry (SIFT-MS) to determine the concentration of formaldehyde in the headspace of urine from patients suffering from bladder and prostate cancer and from several healthy subjects as controls. We address the potential problems associated with the use of ion chemistry to quantify formaldehyde in the presence of the relatively large number densities of water molecules and show that formaldehyde can be quantified in urine headspace using analysis by SIFT-MS. These studies show that formaldehyde is clearly elevated in the headspace of the urine from the cancer patients as compared with urine from the healthy controls. Thus, with further improvements in the methodology and the sensitivity of our SIFT-MS technique, formaldehyde quantification in urine headspace using this new analytical method could be a valuable non-invasive indicator of the presence of early-stage tumours in the body.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619fcc6df8d1c1a4f668156fdefb4fc1 https://pubmed.ncbi.nlm.nih.gov/10407324 Zobrazit plný text záznamu Plný text